Effects of high-intensity interval training on cardiac remodelling, function and coronary microcirculation in de novo heart transplant patients: a substudy of the HITTS randomised controlled trial.

Autor:	Rafique M; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Solberg OG; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Gullestad L; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; KG Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway., Bendz B; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Murbræch K; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Nytrøen K; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Rolid K; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Lunde K; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	BMJ open sport & exercise medicine [BMJ Open Sport Exerc Med] 2023 Jul 09; Vol. 9 (3), pp. e001331. Date of Electronic Publication: 2023 Jul 09 (Print Publication: 2023).
DOI:	10.1136/bmjsem-2022-001331
Abstrakt:	Objectives: High-intensity interval training (HIT) improves peak oxygen consumption (VO2peak) in de novo heart transplant (HTx) recipients. It remains unclear whether this improvement early after HTx is solely dependent on peripheral adaptations, or due to a linked chain of central and peripheral adaptations. The objective of this study was to determine whether HIT results in structural and functional adaptations in the cardiovascular system. Methods: Eighty-one de novo HTx recipients were randomly assigned to participate in either 9 months of supervised HIT or standard care exercise-based rehabilitation. Cardiac function was assessed by echocardiogram and the coronary microcirculation with the index of microcirculatory resistance (IMR) at baseline and 12 months after HTx. Results: Cardiac function as assessed by global longitudinal strain was significantly better in the HIT group than in the standard care group (16.3±1.2% vs 15.6±2.2%, respectively, treatment effect = -1.1% (95% CI -2.0% to -0.2%), p=0.02), as was the end-diastolic volume (128.5±20.8 mL vs 123.4±15.5 mL, respectively, treatment effect=4.9 mL (95% CI 0.5 to 9.2 mL), p=0.03). There was a non-significant tendency for IMR to indicate improved microcirculatory function (13.8±8.0 vs 16.8±12.0, respectively, treatment effect = -4.3 (95% CI -9.1 to 0.6), p=0.08). Conclusion: When initiated early after HTx, HIT leads to both structural and functional cardiovascular adaptations. Trial Registration Number: NCT01796379. Competing Interests: Competing interests: MR received institutional research grants from Stiftelsen DAM; LG received personal fees from Astra Zeneca, Boehringer Ingelheim, Novartis, and Amgen during the conduct of the study; None of the other authors have a conflict of interest to disclose. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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