Assessment of Viral and Clinical Characteristics Among Patients With Chronic Hepatitis B Virus Infection in Georgia.

Autor: Zakalashvili M; Hepatology and Gastroenterology Department, Medical Center Mrcheveli, Tbilisi, Georgia.; University of Georgia, Tbilisi, Georgia., Zarkua J; Hepatology and Gastroenterology Department, Medical Center Mrcheveli, Tbilisi, Georgia.; University of Georgia, Tbilisi, Georgia., Metreveli D; Hepatology and Gastroenterology Department, Medical Center Mrcheveli, Tbilisi, Georgia., Abzianidze T; Health Research Union / Clinic NeoLab, Tbilisi, Georgia.; University of Georgia, Tbilisi, Georgia., Butsashvili M; Health Research Union / Clinic NeoLab, Tbilisi, Georgia.; University of Georgia, Tbilisi, Georgia., Kamkamidze G; Health Research Union / Clinic NeoLab, Tbilisi, Georgia.; University of Georgia, Tbilisi, Georgia.
Jazyk: angličtina
Zdroj: Journal of clinical and experimental hepatology [J Clin Exp Hepatol] 2023 Jul-Aug; Vol. 13 (4), pp. 624-628. Date of Electronic Publication: 2023 Feb 10.
DOI: 10.1016/j.jceh.2023.02.004
Abstrakt: Background: Hepatitis B virus infection (HBV) is one of the major healthcare problems in Georgia. To achieve viral hepatitis elimination, gaps in diagnosis and management of chronic HBV infection need to be addressed. The aim of our study was to collect data on clinical and viral characteristics of patients with chronic HBV infection to estimate the proportion of patients who may need antiviral treatment.
Methods: All relevant deidentified data about demographic, clinical, and viral characteristics were extracted from patients' medical records. Descriptive statistical analyses were done for univariate assessment of demographic, virologic, and clinical characteristics. Chi-square test was used to assess the associations between HBV-DNA level, HBeAg, alanine aminotransferase (ALT), and liver fibrosis.
Results: In total, 96% (124/129) of patients with chronic HBV infection are HBeAg-negative; 84% (145/173) had no or mild fibrosis, and 3% (6/162) had advanced liver fibrosis/cirrhosis. Sixty-five out of 126 (51%) patients were classified as HBeAg-positive or HBeAg-negative chronic HBV infection (without hepatitis); 11 (9%) as chronic hepatitis B; 46 (37%) had not classified in any of the known HBV phases, while 30 of them (24% out of total) had high viral load and normal ALT. Statistically significant association was seen between high HBV-DNA and HBeAg-positivity ( P  = .043). High ALT level was also associated with liver fibrosis ( P  = .015). Significant positive correlation between age and the presence of moderate or advanced liver fibrosis was observed ( P  = .002).
Conclusion: This is the first study about the clinical and viral characteristics of patients with chronic HBV infection in Georgia. The vast majority were HBeAg-negative, only 3% had advanced liver diseases; about half of patients had inactive diseases. However, one out of four patients had a high viral load but normal ALT. By the evaluation of HBV phases, we estimated that 12%-36% of patients with chronic HBV monoinfection require antiviral treatment.
(© 2023 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: