Sonoactivated Cascade Fenton Reaction Enhanced by Synergistic Modulation of Electron-Hole Separation for Improved Tumor Therapy.

Autor: Zhang SL; College of Science, Huazhong Agricultural University, Wuhan, 430070, China., Liu C; Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190, China., Li ZX; College of Science, Huazhong Agricultural University, Wuhan, 430070, China., Guan YH; Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190, China., Ge L; College of Science, Huazhong Agricultural University, Wuhan, 430070, China., Sun Q; Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China., Liu JA; College of Science, Huazhong Agricultural University, Wuhan, 430070, China., Lin YJ; National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research, Huazhong Agricultural University, Wuhan, 430070, China., Yang ZX; College of Science, Huazhong Agricultural University, Wuhan, 430070, China., Qiao ZY; Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190, China., Wang H; Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, 100190, China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2023 Oct; Vol. 12 (26), pp. e2300982. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1002/adhm.202300982
Abstrakt: Chemodynamic therapy (CDT) is an emerging targeted treatment technique for tumors via the generation of highly cytotoxic hydroxyl radical (·OH) governed by tumor microenvironment-assisted Fenton reaction. Despite high effectiveness, it faces limitations like low reaction efficiency and limited endogenous H 2 O 2 , compromising its therapeutic efficacy. This study reports a novel platform with enhanced CDT performance by in situ sono-activated cascade Fenton reaction. A piezoelectric g-C 3 N 4 (Au-Fe-g-C 3 N 4 ) nanosheet is developed via sono-activated synergistic effect/H 2 O 2 self-supply mediated cascade Fenton reaction, realizing in situ ultrasound activated cascade Fenton reaction kinetics by synergistic modulation of electron-hole separation. The nanosheets consist of piezoelectric g-C 3 N 4 nanosheet oxidizing H 2 O to highly reactive H 2 O 2 from the valence band, Fe 3+ /Fe 2+ cycling activated by conduction band to generate ·OH, and Au nanoparticles that lower the bandgap and further adopt electrons to generate more 1 O 2 , resulting in improved CDT and sonodynamic therapy (SDT). Moreover, the Au-Fe-g-C 3 N 4 nanosheet is further modified by the targeted peptide to obtain P-Au-Fe-g-C 3 N 4 , which inhibits tumor growth in vivo effectively by generating reactive oxygen species (ROS). These results demonstrated that the sono-activated modulation translates into a high-efficiency CDT with a synergistic effect using SDT for improved anti-tumor therapy.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: