| Autor: |
Gaulton TG; Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Martin K; Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Xin Y; Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Victor M; Pulmonary Division, Heart Institute (InCor), University of São Paulo, São Paulo, Brazil.; Medical Electrical Devices Laboratory (LabMed), Electronics Engineering, Aeronautics Institute of Technology, Sao Jose dos Campos, Brazil., Ribeiro De Santis Santiago R; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States., Britto Passos Amato M; Pulmonary Division, Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Berra L; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States., Cereda M; Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States. |
| Abstrakt: |
Management of acute respiratory distress syndrome (ARDS) is classically guided by protecting the injured lung and mitigating damage from mechanical ventilation. Yet the natural history of ARDS is also dictated by disruption in lung perfusion. Unfortunately, diagnosis and treatment are hampered by the lack of bedside perfusion monitoring. Electrical impedance tomography is a portable imaging technique that can estimate regional lung perfusion in experimental settings from the kinetic analysis of a bolus of an indicator with high conductivity. Hypertonic sodium chloride has been the standard indicator. However, hypertonic sodium chloride is often inaccessible in the hospital, limiting practical adoption. We investigated whether regional lung perfusion measured using electrical impedance tomography is comparable between indicators. Using a swine lung injury model, we determined regional lung perfusion (% of total perfusion) in five pigs, comparing 12% sodium chloride to 8.4% sodium bicarbonate across stages of lung injury and experimental conditions (body position, positive end-expiratory pressure). Regional lung perfusion for four lung regions was determined from maximum slope analysis of the indicator-based impedance signal. Estimates of regional lung perfusion between indicators were compared in the lung overall and within four lung regions. Regional lung perfusion estimated with a sodium bicarbonate indicator agreed with a hypertonic sodium chloride indicator overall (mean bias 0%, limits of agreement -8.43%, 8.43%) and within lung quadrants. The difference in regional lung perfusion between indicators did not change across experimental conditions. Sodium bicarbonate may be a comparable indicator to estimate regional lung perfusion using electrical impedance tomography. NEW & NOTEWORTHY Electrical impedance tomography is an emerging tool to measure regional lung perfusion using kinetic analysis of a conductive indicator. Hypertonic sodium chloride is the standard agent used. We measured regional lung perfusion using another indicator, comparing hypertonic sodium chloride to sodium bicarbonate in an experimental swine lung injury model. We found strong agreement between the two indicators. Sodium bicarbonate may be a comparable indicator to measure regional lung perfusion with electrical impedance tomography. |
