Anti-infective activities of long-chain fatty acids against foodborne pathogens.
| Autor: | Borreby C; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark., Lillebæk EMS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark., Kallipolitis BH; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | FEMS microbiology reviews [FEMS Microbiol Rev] 2023 Jul 05; Vol. 47 (4). |
| DOI: | 10.1093/femsre/fuad037 |
| Abstrakt: | Free fatty acids (FFAs) have long been acknowledged for their antimicrobial activity. More recently, long-chain FFAs (>12 carbon atoms) are receiving increased attention for their potent antivirulence activity against pathogenic bacteria. In the gastrointestinal tract, foodborne pathogens encounter a variety of long-chain FFAs derived from the diet, metabolic activities of the gut microbiota, or the host. This review highlights the role of long-chain FFAs as signaling molecules acting to inhibit the infectious potential of important foodborne pathogens, including Salmonella and Listeria monocytogenes. Various long-chain FFAs interact with sensory proteins and transcriptional regulators controlling the expression of infection-relevant genes. Consequently, long-chain FFAs may act to disarm bacterial pathogens of their virulence factors. Understanding how foodborne pathogens sense and respond to long-chain FFAs may enable the design of new anti-infective approaches. (© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|