Immune sensing of food allergens promotes avoidance behaviour.

Autor: Florsheim EB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. esther.florsheim@asu.edu.; School of Life Sciences, Arizona State University, Tempe, AZ, USA. esther.florsheim@asu.edu.; Biodesign Institute, Center for Health Through Microbiomes, Arizona State University, Tempe, AZ, USA. esther.florsheim@asu.edu., Bachtel ND; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Cullen JL; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Lima BGC; School of Life Sciences, Arizona State University, Tempe, AZ, USA.; Department of Pharmacology, University of São Paulo, São Paulo, Brazil.; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Godazgar M; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Carvalho F; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Chatain CP; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Zimmer MR; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Zhang C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gautier G; Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France., Launay P; Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS EMR8252, Université Paris Cité, Paris, France., Wang A; Department of Medicine (Rheumatology, Allergy & Immunology), Yale University School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Dietrich MO; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Medzhitov R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. ruslan.medzhitov@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. ruslan.medzhitov@yale.edu.; Tananbaum Center for Theoretical and Analytical Human Biology, Yale University School of Medicine, New Haven, CT, USA. ruslan.medzhitov@yale.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2023 Aug; Vol. 620 (7974), pp. 643-650. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.1038/s41586-023-06362-4
Abstrakt: In addition to its canonical function of protection from pathogens, the immune system can also alter behaviour 1,2 . The scope and mechanisms of behavioural modifications by the immune system are not yet well understood. Here, using mouse models of food allergy, we show that allergic sensitization drives antigen-specific avoidance behaviour. Allergen ingestion activates brain areas involved in the response to aversive stimuli, including the nucleus of tractus solitarius, parabrachial nucleus and central amygdala. Allergen avoidance requires immunoglobulin E (IgE) antibodies and mast cells but precedes the development of gut allergic inflammation. The ability of allergen-specific IgE and mast cells to promote avoidance requires cysteinyl leukotrienes and growth and differentiation factor 15. Finally, a comparison of C57BL/6 and BALB/c mouse strains revealed a strong effect of the genetic background on the avoidance behaviour. These findings thus point to antigen-specific behavioural modifications that probably evolved to promote niche selection to avoid unfavourable environments.
(© 2023. The Author(s).)
Databáze: MEDLINE
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