The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles.

Autor: Ortiz GGR; Laboratory of Basic Psychology, Behavioral Analysis and Programmatic Development (PAD-LAB), Catholic University of Cuenca, Cuenca, Ecuador., Zaidi NH; Umanand Prasad School of Medicine and Health Science, The University of Fiji, Saweni Campus, Lautoka, Fiji., Saini RS; COAMS King Khalid University, Abha, Saudi Arabia., Ramirez Coronel AA; School of Medicine and Health Sciences, University of Rosario, Bogotá, Colombia., Alsandook T; Dentistry Department, Al-Turath University College, Baghdad, Iraq., Hadi Lafta M; Iraqi Ministry of Education, Baghdad, Iraq., Arias-Gonzáles JL; Department of Social Sciences, Faculty of Social Studies, Pontifical University of Peru., Amin AH; Zoology Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt., Maaliw Iii RR; College of Engineering, Southern Luzon State University, Lucban, Quezon, Philippines. Electronic address: rmaaliw@slsu.edu.ph.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2023 Sep; Vol. 122, pp. 110531. Date of Electronic Publication: 2023 Jul 10.
DOI: 10.1016/j.intimp.2023.110531
Abstrakt: Autoimmune diseases are complex, chronic inflammatory conditions initiated by the loss of immunological tolerance to self-antigens. Nowadays, there is no effective and useful therapy for autoimmune diseases, and the existing medications have some limitations due to their nonspecific targets and side effects. During the last few decades, it has been established that mesenchymal stem cells (MSCs) have immunomodulatory functions. It is proposed that MSCs can exert an important therapeutic effect on autoimmune disorders. In parallel with these findings, several investigations have shown that MSCs alleviate autoimmune diseases. Intriguingly, the results of studies have demonstrated that the effective roles of MSCs in autoimmune diseases do not depend on direct intercellular communication but on their ability to release a wide spectrum of paracrine mediators such as growth factors, cytokines and extracellular vehicles (EVs). EVs that range from 50 to 5,000 nm were produced by almost any cell type, and these nanoparticles participate in homeostasis and intercellular communication via the transfer of a broad range of biomolecules such as modulatory proteins, nucleic acids (DNA and RNA), lipids, cytokines, and metabolites. EVs derived from MSCs display the exact properties of MSCs and can be safer and more beneficial than their parent cells. In this review, we will discuss the features of MSCs and their EVs, EVs biogenesis, and their cargos, and then we will highlight the existing discoveries on the impacts of EVs from MSCs on autoimmune diseases such as multiple sclerosis, arthritis rheumatic, inflammatory bowel disease, Type 1 diabetes mellitus, systemic lupus erythematosus, autoimmune liver diseases, Sjögren syndrome, and osteoarthritis, suggesting a potential alternative for autoimmune conditions therapy.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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