Cytomegalovirus infection induces Alzheimer's disease-associated alterations in tau.

Autor: Mody PH; Division of Biology, Texas Woman's University, 304 Administration Drive, Denton, TX, 76204, USA.; Current affiliation: University of Texas Southwestern Medical Center, Dallas, USA., Marvin KN; Division of Biology, Texas Woman's University, 304 Administration Drive, Denton, TX, 76204, USA., Hynds DL; Division of Biology, Texas Woman's University, 304 Administration Drive, Denton, TX, 76204, USA., Hanson LK; Division of Biology, Texas Woman's University, 304 Administration Drive, Denton, TX, 76204, USA. lhanson@twu.edu.
Jazyk: angličtina
Zdroj: Journal of neurovirology [J Neurovirol] 2023 Aug; Vol. 29 (4), pp. 400-415. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.1007/s13365-022-01109-9
Abstrakt: Alzheimer's disease (AD) manifests with loss of neurons correlated with intercellular deposition of amyloid (amyloid plaques) and intracellular neurofibrillary tangles of hyperphosphorylated tau. However, targeting AD hallmarks has not as yet led to development of an effective treatment despite numerous clinical trials. A better understanding of the early stages of neurodegeneration may lead to development of more effective treatments. One underexplored area is the clinical correlation between infection with herpesviruses and increased risk of AD. We hypothesized that similar to work performed with herpes simplex virus 1 (HSV1), infection with the cytomegalovirus (CMV) herpesvirus increases levels and phosphorylation of tau, similar to AD tauopathy. We used murine CMV (MCMV) to infect mouse fibroblasts and rat neuronal cells to test our hypothesis. MCMV infection increased steady-state levels of primarily high molecular weight forms of tau and altered the patterns of tau phosphorylation. Both changes required viral late gene products. Glycogen synthase kinase 3 beta (GSK3β) was upregulated in the HSVI model, but inhibition with lithium chloride suggested that this enzyme is unlikely to be involved in MCMV infection mediated tau phosphorylation. Thus, we confirm that MCMV, a beta herpes virus, like alpha herpes viruses (e.g., HSV1), can promote tau pathology. This suggests that CMV infection can be useful as another model system to study mechanisms leading to neurodegeneration. Since MCMV infects both mice and rats as permissive hosts, our findings from tissue culture can likely be applied to a variety of AD models to study development of abnormal tau pathology.
(© 2023. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc.)
Databáze: MEDLINE
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