Topical capsaicin for the management of painful diabetic neuropathy: a narrative systematic review.

Autor: Goodwin B; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Chiplunkar M; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Salerno R; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Coombs K; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Sannoh U; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Shah V; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Averell N; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Al-Shebab U; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA., Janora D; Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ 08043, USA.; Neuromuscular Institute, Rowan Medicine, Stratford, NJ 08043, USA.
Jazyk: angličtina
Zdroj: Pain management [Pain Manag] 2023 May; Vol. 13 (5), pp. 309-316. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.2217/pmt-2023-0006
Abstrakt: Aim: To investigate the potential benefit of topical capsaicin formulations. Materials & methods: A narrative systematic review was employed. Results: About 8% capsaicin patches were found to significantly reduce symptoms of diabetic peripheral neuropathy. Capsaicin was found to improve sleep quality (p = 0.02). Capsaicin patch exposure for 60 min showed significant reduction in symptoms (-32.8%). Capsaicin cream significantly reduced pain at weeks two and six (p = 0.003 and p = 0.03, respectively), but not at week eight in comparative studies. 0.025% capsaicin gel had an insignificant reduction in pain compared with placebo (p = 0.53), however 0.075% was found to be significant (p = 0.038). Capsaicin cream did not have superior improvement of pain as compared with clonidine gel (p = 0.931). The most common adverse events included application site discomfort, erythema and burning. Conclusion: Topical capsaicin treatments are a potentially beneficial peripherally acting medication. Further research is needed to determine the best means of ameliorating the side effects of treatments.
Databáze: MEDLINE
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