| Autor: |
Chiorean EG; Fred Hutchinson Cancer Center., Chiaro MD; University of Colorado Cancer Center., Tempero MA; UCSF Helen Diller Family Comprehensive Cancer Center., Malafa MP; Moffitt Cancer Center., Benson AB; Robert H. Lurie Comprehensive Cancer Center of Northwestern University., Cardin DB; Vanderbilt-Ingram Cancer Center., Christensen JA; University of Michigan Rogel Cancer Center., Chung V; City of Hope National Medical Center., Czito B; Duke Cancer Institute., Dillhoff M; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute., Donahue TR; UCLA Jonsson Comprehensive Cancer Center., Dotan E; Fox Chase Cancer Center., Fountzilas C; Roswell Park Comprehensive Cancer Center., Glazer ES; The University of Tennessee Health Science Center., Hardacre J; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute., Hawkins WG; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine., Klute K; Fred & Pamela Buffett Cancer Center., Ko AH; UCSF Helen Diller Family Comprehensive Cancer Center., Kunstman JW; Yale Cancer Center/Smilow Cancer Hospital., LoConte N; University of Wisconsin Carbone Cancer Center., Lowy AM; UC San Diego Moores Cancer Center., Masood A; Indiana University Melvin and Bren Simon Comprehensive Cancer Center., Moravek C; Pancreatic Cancer Action Network., Nakakura EK; UCSF Helen Diller Family Comprehensive Cancer Center., Narang AK; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins., Nardo L; UC Davis Comprehensive Cancer Center., Obando J; Duke Cancer Institute., Polanco PM; UT Southwestern Simmons Comprehensive Cancer Center., Reddy S; O'Neal Comprehensive Cancer Center at UAB., Reyngold M; Memorial Sloan Kettering Cancer Center., Scaife C; Huntsman Cancer Institute at the University of Utah., Shen J; Stanford Cancer Institute., Truty MJ; Mayo Clinic Comprehensive Cancer Center., Vollmer C; Abramson Cancer Center at the University of Pennsylvania., Wolff RA; The University of Texas MD Anderson Cancer Center., Wolpin BM; Dana-Farber/Brigham and Women's Cancer Center., Rn BM; National Comprehensive Cancer Network., Lubin S; National Comprehensive Cancer Network., Darlow SD; National Comprehensive Cancer Network. |
| Abstrakt: |
Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma. |
