New insight into the causes, consequences, and correction of hematopoietic stem cell aging.

Autor: Mansell E; Erasmus MC Hematology, Rotterdam, The Netherlands; Division of Molecular Medicine and Gene Therapy, Lund University, Lund, Sweden. Electronic address: s.mansell@erasmusmc.nl., Lin DS; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Loughran SJ; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, England, UK., Milsom MD; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), Heidelberg, Germany; Division of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Trowbridge JJ; The Jackson Laboratory, Bar Harbor, Maine.
Jazyk: angličtina
Zdroj: Experimental hematology [Exp Hematol] 2023 Sep-Oct; Vol. 125-126, pp. 1-5. Date of Electronic Publication: 2023 Jul 09.
DOI: 10.1016/j.exphem.2023.07.002
Abstrakt: Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways, and downregulation of DNA repair pathways. Cellular aging of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes a predisposition to anemia, adaptive immune compromise, myelodys, plasia, and malignancy. Most hematologic diseases are strongly associated with age. But what is the biological foundation for decreased fitness with age? And are there therapeutic windows to resolve age-related hematopoietic decline? These questions were the focus of the International Society for Experimental Hematology (ISEH) New Investigator Committee Fall 2022 Webinar. This review touches on the latest insights from two leading laboratories into inflammatory- and niche-driven stem cell aging and includes speculation on strategies to prevent or correct age-related decline in HSC function.
Competing Interests: Conflict of Interest Disclosure The authors do not have any conflicts of interest to declare in relation to this work
(Copyright © 2023 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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