Childhood trajectories of internalising and externalising problems associated with a polygenic risk score for neuroticism in a UK birth cohort study.
Autor: | Costantini I; Centre for Academic Mental Health University of Bristol Bristol UK.; Department of Population Health Sciences, Bristol Medical School University of Bristol Bristol UK., Sallis H; Centre for Academic Mental Health University of Bristol Bristol UK.; Department of Population Health Sciences, Bristol Medical School University of Bristol Bristol UK.; Medical Research Council (MRC) Integrative Epidemiology Unit University of Bristol Bristol UK.; School of Psychological Science University of Bristol Bristol UK., Tilling K; Department of Population Health Sciences, Bristol Medical School University of Bristol Bristol UK.; Medical Research Council (MRC) Integrative Epidemiology Unit University of Bristol Bristol UK., Major-Smith D; Department of Population Health Sciences, Bristol Medical School University of Bristol Bristol UK.; Medical Research Council (MRC) Integrative Epidemiology Unit University of Bristol Bristol UK.; Centre for Academic Child Health Bristol Medical School University of Bristol Bristol UK., Pearson RM; Centre for Academic Mental Health University of Bristol Bristol UK.; Department of Population Health Sciences, Bristol Medical School University of Bristol Bristol UK.; Medical Research Council (MRC) Integrative Epidemiology Unit University of Bristol Bristol UK.; Department of Psychology Manchester Metropolitan University Manchester UK., Kounali DZ; Centre for Academic Mental Health University of Bristol Bristol UK.; Department of Population Health Sciences, Bristol Medical School University of Bristol Bristol UK. |
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Jazyk: | angličtina |
Zdroj: | JCPP advances [JCPP Adv] 2023 Feb 22; Vol. 3 (1), pp. e12141. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2023). |
DOI: | 10.1002/jcv2.12141 |
Abstrakt: | Background: Neuroticism represents a personality disposition towards experiencing negative emotions more frequently and intensely. Longitudinal studies suggest that neuroticism increases risk of several psychological problems. Improved understanding of how this trait manifests in early life could help inform preventative strategies in those liable to neuroticism. Methods: This study explored how a polygenic risk score for neuroticism (NEU PRS) is expressed from infancy to late childhood across various psychological outcomes using multivariable linear and ordinal regression models. In addition, we employed a three-level mixed-effect model to characterise child internalising and externalising trajectories and estimate how a child PRS associated with both their overall levels and rates of change in 5279 children aged 3-11 in the Avon Longitudinal Study of Parents and Children cohort. Results: We found evidence that the NEU PRS was associated with a more emotionally sensitive temperament in early infancy in addition to higher emotional and behavioural problems and a higher risk of meeting diagnostic criteria for a variety of clinical disorders, particularly anxiety disorders, in childhood. The NEU PRS was associated with overall levels of internalising and externalising trajectories, with a larger magnitude of association on the internalising trajectory. The PRS was also associated with slower rates of reduction of internalising problems across childhood. Conclusions: Our findings using a large, well-characterised birth cohort study suggest that phenotypic manifestations of a PRS for adult neuroticism can be detected as early as in infancy and that this PRS associates with several mental health problems and differences in emotional trajectories across childhood. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 The Authors. JCPP Advances published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.) |
Databáze: | MEDLINE |
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