How coupled slow oscillations, spindles and ripples coordinate neuronal processing and communication during human sleep.

Autor: Staresina BP; Department of Experimental Psychology, University of Oxford, Oxford, UK. bernhard.staresina@psy.ox.ac.uk.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK. bernhard.staresina@psy.ox.ac.uk., Niediek J; Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.; Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel., Borger V; Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany., Surges R; Department of Epileptology, University of Bonn Medical Center, Bonn, Germany., Mormann F; Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2023 Aug; Vol. 26 (8), pp. 1429-1437. Date of Electronic Publication: 2023 Jul 10.
DOI: 10.1038/s41593-023-01381-w
Abstrakt: Learning and plasticity rely on fine-tuned regulation of neuronal circuits during offline periods. An unresolved puzzle is how the sleeping brain, in the absence of external stimulation or conscious effort, coordinates neuronal firing rates (FRs) and communication within and across circuits to support synaptic and systems consolidation. Using intracranial electroencephalography combined with multiunit activity recordings from the human hippocampus and surrounding medial temporal lobe (MTL) areas, we show that, governed by slow oscillation (SO) up-states, sleep spindles set a timeframe for ripples to occur. This sequential coupling leads to a stepwise increase in (1) neuronal FRs, (2) short-latency cross-correlations among local neuronal assemblies and (3) cross-regional MTL interactions. Triggered by SOs and spindles, ripples thus establish optimal conditions for spike-timing-dependent plasticity and systems consolidation. These results unveil how the sequential coupling of specific sleep rhythms orchestrates neuronal processing and communication during human sleep.
(© 2023. The Author(s).)
Databáze: MEDLINE
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