Effect of Obesity on Clinical Characteristics of Primary Aldosteronism Patients at Diagnosis and Postsurgical Response.

Autor:	Ruiz-Sánchez JG; Endocrinology & Nutrition Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS FJD, UAM), Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain., Paja-Fano M; Endocrinology & Nutrition Department, OSI Bilbao-Basurto, Medicine Department, Basque Country University, Hospital Universitario de Basurto, 48013 Bilbao, Spain., González Boillos M; Endocrinology & Nutrition Department, Hospital Universitario de Castellón, 12004 Castellón, Spain., Pla Peris B; Endocrinology & Nutrition Department, Hospital Universitario de Castellón, 12004 Castellón, Spain., Pascual-Corrales E; Endocrinology & Nutrition Department, Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., García Cano AM; Biochemistry Department, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Parra Ramírez P; Endocrinology & Nutrition Department, Hospital Universitario La Paz, 28046 Madrid, Spain., Martín Rojas-Marcos P; Endocrinology & Nutrition Department, Hospital Universitario La Paz, 28046 Madrid, Spain., Vicente Delgado A; Endocrinology & Nutrition Department, Hospital Universitario de Toledo, 45007 Toledo, Spain., Gómez Hoyos E; Endocrinology & Nutrition Department, Hospital Universitario de Valladolid, 47003 Valladolid, Spain., Ferreira R; Endocrinology & Nutrition Department, Hospital Universitario de La Princesa, 28006 Madrid, Spain., García Sanz I; General & Digestive Surgery Department, Hospital Universitario de La Princesa, 28006 Madrid, Spain., Recasens Sala M; Endocrinology & Nutrition Department, Institut Català de la Salut Girona, 17007 Girona, Spain., Barahona San Millan R; Endocrinology & Nutrition Department, Institut Català de la Salut Girona, 17007 Girona, Spain., Picón César MJ; Endocrinology & Nutrition Department, Hospital Universitario Virgen de la Victoria de Málaga, IBIMA, 29010 Málaga, Spain.; CIBEROBN, 28029 Madrid, Spain., Díaz Guardiola P; Endocrinology & Nutrition Department, Hospital Universitario Infanta Sofía, 28702 Madrid, Spain., García González JJ; Endocrinology & Nutrition Department, Hospital Universitario Virgen de la Macarena, 41009 Sevilla, Spain., Perdomo CM; Endocrinology & Nutrition Department, Clínica Universidad de Navarra, 31008 Pamplona, Spain., Manjón Miguélez L; Endocrinology & Nutrition Department, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, 33011 Oviedo, Spain., García Centeno R; Endocrinology & Nutrition Department, Hospital Universitario Gregorio Marañón, 28007 Madrid, Spain., Percovich JC; Endocrinology & Nutrition Department, Hospital Universitario Gregorio Marañón, 28007 Madrid, Spain., Rebollo Román Á; Endocrinology & Nutrition Department, Hospital Reina Sofía, 14004 Córdoba, Spain., Gracia Gimeno P; Endocrinology & Nutrition Department, Hospital Royo Villanova, 50015 Zaragoza, Spain., Robles Lázaro C; Endocrinology & Nutrition Department, Complejo Universitario de Salamanca, 37007 Salamanca, Spain., Morales-Ruiz M; Biochemistry and Molecular Genetics Department-CDB, Hospital Clinic, IDIBAPS, CIBERehd, 08036 Barcelona, Spain., Hanzu FA; Endocrinology & Nutrition Department, Hospital Clinic, IDIBAPS, CIBERDEM, Universitat de Barcelona, 08036 Barcelona, Spain., Araujo-Castro M; Endocrinology & Nutrition Department, Instituto de Investigación Biomédica Ramón y Cajal (IRYCIS), Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.; Department of Medicine, University of Alcalá, 28801 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Dec 21; Vol. 109 (1), pp. e379-e388.
DOI:	10.1210/clinem/dgad400
Abstrakt:	Context: Patients with obesity have an overactivated renin-angiotensin-aldosterone system (RAAS) that is associated with essential hypertension. However, the influence of obesity in primary aldosteronism (PA) is unknown. Objective: We analyzed the effect of obesity on the characteristics of PA, and the association between obesity and RAAS components. Methods: A retrospective study was conducted of the Spanish PA Registry (SPAIN-ALDO Registry), which included patients with PA seen at 20 tertiary centers between 2018 and 2022. Differences between patients with and without obesity were analyzed. Results: A total of 415 patients were included; 189 (45.5%) with obesity. Median age was 55 years (range, 47.3-65.2 years) and 240 (58.4%) were male. Compared to those without obesity, patients with obesity had higher rates of diabetes mellitus, chronic kidney disease, obstructive apnea syndrome, left ventricular hypertrophy, prior cardiovascular events, higher means of systolic blood pressure, and required more antihypertensive drugs. Patients with PA and obesity also had higher values of serum glucose, glycated hemoglobin A1c, creatinine, uric acid, and triglycerides, and lower levels of high-density lipoprotein cholesterol. Levels of blood aldosterone (PAC) and renin were similar between patients with and without obesity. Body mass index was not correlated with PAC nor renin. The rates of adrenal lesions on imaging studies, as well as the rates of unilateral disease assessed by adrenal vein sampling or I-6β-iodomethyl-19-norcholesterol scintigraphy, were similar between groups. Conclusion: Obesity in PA patients involves a worse cardiometabolic profile, and need for more antihypertensive drugs but similar PAC and renin levels, and rates of adrenal lesions and lateral disease than patients without obesity. However, obesity implicates a lower rate of hypertension cure after adrenalectomy. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
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