3D-conformal very-high energy electron therapy as candidate modality for FLASH-RT: A treatment planning study for glioblastoma and lung cancer.
Autor: | Böhlen TT; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Germond JF; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Traneus E; RaySearch Laboratories, Stockholm, Sweden., Vallet V; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Desorgher L; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Ozsahin EM; Department of Radiation Oncology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Bochud F; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Bourhis J; Department of Radiation Oncology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Moeckli R; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland. |
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Jazyk: | angličtina |
Zdroj: | Medical physics [Med Phys] 2023 Sep; Vol. 50 (9), pp. 5745-5756. Date of Electronic Publication: 2023 Jul 10. |
DOI: | 10.1002/mp.16586 |
Abstrakt: | Background: Pre-clinical ultra-high dose rate (UHDR) electron irradiations on time scales of 100 ms have demonstrated a remarkable sparing of brain and lung tissues while retaining tumor efficacy when compared to conventional dose rate irradiations. While clinically-used gantries and intensity modulation techniques are too slow to match such time scales, novel very-high energy electron (VHEE, 50-250 MeV) radiotherapy (RT) devices using 3D-conformed broad VHEE beams are designed to deliver UHDR treatments that fulfill these timing requirements. Purpose: To assess the dosimetric plan quality obtained using VHEE-based 3D-conformal RT (3D-CRT) for treatments of glioblastoma and lung cancer patients and compare the resulting treatment plans to those delivered by standard-of-care intensity modulated photon RT (IMRT) techniques. Methods: Seven glioblastoma patients and seven lung cancer patients were planned with VHEE-based 3D-CRT using 3 to 16 coplanar beams with equidistant angular spacing and energies of 100 and 200 MeV using a forward planning approach. Dose distributions, dose-volume histograms, coverage (V Results: Mean differences of V Conclusions: VHEE-based 3D-CRT may deliver conformal treatments to simple, mostly convex target shapes in the brain and the thorax with a limited number of critical adjacent OAR using a limited number of beams (as low as 3 to 7). Using such treatment techniques, a dosimetric plan quality comparable to that of standard-of-care IMRT can be achieved. Hence, from a treatment planning perspective, 3D-conformal UHDR VHEE treatments delivered on time scales of 100 ms represent a promising candidate technique for the clinical transfer of the FLASH effect. (© 2023 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.) |
Databáze: | MEDLINE |
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