Vitamin D and polycystic ovary syndrome (PCOS): a review.

Autor:	Mohan A; Karachi Medical & Dental College., Haider R; Karachi Medical & Dental College., Fakhor H; Asselin Hedelin Hospital, Yvetot, France., Hina F; Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan., Kumar V; The Brooklyn Hospital Center, Brooklyn, NY., Jawed A; Ziauddin University., Majumder K; Chittagong Medical College, Chittagong, Bangladesh., Ayaz A; Karachi Medical & Dental College., Lal PM; Ziauddin University., Tejwaney U; Valley Health System, Ridgewood, NJ., Ram N; Aga Khan University Hospital, Karachi., Kazeem S; The Brooklyn Hospital Center, Brooklyn, NY.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2023 Jun 05; Vol. 85 (7), pp. 3506-3511. Date of Electronic Publication: 2023 Jun 05 (Print Publication: 2023).
DOI:	10.1097/MS9.0000000000000879
Abstrakt:	A common health problem known as polycystic ovarian syndrome (PCOS), is characterized by irregular periods, an excess of androgen production, and polycystic ovaries. It is one of the most prevalent endocrine disorders in women of reproductive age, affecting 4-20% of women worldwide. Numerous studies have found a connection between the onset and symptoms of PCOS and Vitamin D insufficiency. Vitamin D insufficiency causes calcium dysregulation and follicular arrest in women with PCOS, which is connected to menstrual irregularities and fertility issues. Studies have connected PCOS metabolic alterations to VDR polymorphisms such as iApa-I, Taq-I, Cdx2, and Fok-I. Insulin resistance is directly related to Vitamin D, is one of the most distinctive characteristics of the PCOS phenotype. Thus, it is suggested that Vitamin D therapy may help PCOS patients with their insulin sensitivity. In addition to insulin resistance, cardiovascular issues are a second metabolic disturbance that PCOS patients with low Vitamin D levels experience. Dyslipidemia is not linked to an increased risk of cardiovascular disease in PCOS-affected women. Vitamin D dramatically improves glucose metabolism by increasing insulin production, insulin receptor expression and reducing pro-inflammatory cytokines. The effect of Vitamin D on the metabolic and reproductive dysfunctions associated with PCOS may be mediated by an overall impact on insulin resistance. Vitamin D supplementation improved menstrual periods, increased folliculogenesis, and decreased blood testosterone levels in PCOS patients, all of which had a significant impact on the ability to procreate. As a result, it might be a cutting-edge therapeutic strategy for treating PCOS concurrently. Competing Interests: No conflict of interest declared. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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