Definitions of Urinary Tract Infection in Current Research: A Systematic Review.

Autor: Bilsen MP; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Jongeneel RMH; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Schneeberger C; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Platteel TN; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Nieuwkoop C; Department of Internal Medicine, Haga Teaching Hospital, The Hague, The Netherlands.; Health Campus The Hague, Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Mody L; Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Geriatrics Research Education and Clinical Center, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA., Caterino JM; Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA., Geerlings SE; Amsterdam University Medical Center, Department of Internal Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Köves B; Department of Urology, University of Szeged, Szeged, Hungary., Wagenlehner F; Clinic for Urology, Paediatric Urology and Andrology, Justus Liebig University, Giessen, Germany., Conroy SP; Medical Research Council Unit for Lifelong Health and Ageing, University College London, London, United Kingdom., Visser LG; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Lambregts MMC; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2023 Jun 27; Vol. 10 (7), pp. ofad332. Date of Electronic Publication: 2023 Jun 27 (Print Publication: 2023).
DOI: 10.1093/ofid/ofad332
Abstrakt: Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review, we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria, and a positive urine culture were required in 85%, 28%, and 55% of study definitions, respectively. Five studies (11%) required all 3 categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 10 3 to 10 5 colony-forming units/mL. None of the 12 studies including acute cystitis and 2 of 12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9 of 14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI.
Competing Interests: Potential conflicts of interest. All authors: No reported conflicts.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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