Risk assessment for postoperative venous thromboembolism using the modified Caprini risk assessment model in lung cancer.

Autor:	Ding Y; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Thoracic Surgery, The People's Hospital of Kaizhou District, Chongqing, China., Yao L; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Tan T; Chongqing Health Statistics Information Center, Chongqing, China., Li Q; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Shi H; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Tian Y; Department of Medical Affairs, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Franssen AJPM; Department of Surgery, Division of General Thoracic Surgery, Zuyderland Medical Center, Heerlen, The Netherlands., de Loos ER; Department of Surgery, Division of General Thoracic Surgery, Zuyderland Medical Center, Heerlen, The Netherlands., Al Zaidi M; Thoracic and Upper GI Surgeon, Thoracic Surgery Unit, King Abdullah Medical City, Makkah, Saudi Arabia., Cardillo G; Unit of Thoracic Surgery, San Camillo Forlanini Hospital, Rome, Italy.; Unicamillus - Saint Camillus University of Health Sciences, Rome, Italy., Kidane B; Section of Thoracic Surgery, University of Manitoba, Winnipeg, Manitoba, Canada., Grapatsas K; Department of Thoracic Surgery, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany., Wu Q; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang C; Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jazyk:	angličtina
Zdroj:	Journal of thoracic disease [J Thorac Dis] 2023 Jun 30; Vol. 15 (6), pp. 3386-3396. Date of Electronic Publication: 2023 Jun 26.
DOI:	10.21037/jtd-23-776
Abstrakt:	Background: Postoperative venous thromboembolism (VTE) is a well-documented cause of morbidity and mortality in lung cancer patients. However, risk identification remains limited. In this study, we sought to analyze the risk factors for VTE and verify the predictive value of the modified Caprini risk assessment model (RAM). Methods: This prospective single-center study included patients with resectable lung cancer who underwent resection between October 2019 and March 2021. The incidence of VTE was estimated. Logistic regression was used to analyze the risk factors for VTE. Receiver operating characteristic (ROC) curve analysis was performed to test the ability of the modified Caprini RAM to predict VTE. Results: The VTE incidence was 10.5%. Several variables, including age, D-dimer, hemoglobin (Hb), bleeding, and patient confinement to bed were significantly associated with VTE after surgery. The difference between the VTE and non-VTE groups in the high-risk levels was statistically significant (P<0.001), while the low and moderate risk levels showed no significant difference. The combined use of the modified Caprini score and the Hb and D-dimer levels showed an area under the curve (AUC) was 0.822 [95% confidence interval (CI): 0.760-0.855. P<0.001]. Conclusions: The risk-stratification approach of the modified Caprini RAM is not particularly valid after lung resection in our population. The use of the modified Caprini RAM combined with Hb and D-dimer levels shows a good diagnostic performance for VTE prediction in patients with lung cancer undergoing resection. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-23-776/coif). The authors declare no conflicts of interest. (2023 Journal of Thoracic Disease. All rights reserved.)
Databáze:	MEDLINE
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