Tessellation of artificial touch via microstimulation of human somatosensory cortex.

Autor: Greenspon CM; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Shelchkova ND; Committee on Computational Neuroscience, University of Chicago, Chicago, IL., Valle G; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Hobbs TG; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA., Berger-Wolf EI; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Hutchison BC; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH., Dogruoz E; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Verbarschott C; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA., Callier T; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Sobinov AR; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Okorokova EV; Committee on Computational Neuroscience, University of Chicago, Chicago, IL., Jordan PM; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Prasad D; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., He Q; Committee on Computational Neuroscience, University of Chicago, Chicago, IL., Liu F; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA., Kirsch RF; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.; School of Medicine, Case Western Reserve University, Cleveland, OH.; Louis Stokes Cleveland VA Medical Center, Cleveland, OH., Miller JP; School of Medicine, Case Western Reserve University, Cleveland, OH.; The Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH.; Louis Stokes Cleveland VA Medical Center, Cleveland, OH., Lee RC; Schwab Rehabilitation Hospital, Chicago, IL., Satzer D; Department of Neurological Surgery, University of Chicago, Chicago, IL., Gonzalez-Martinez J; Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA., Warnke PC; Department of Neurological Surgery, University of Chicago, Chicago, IL., Miller LE; Department of Neuroscience, Northwestern University, Chicago, IL.; Department of Biomedical Engineering, Northwestern University, Evanston, IL.; Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL.; Shirley Ryan Ability Lab, Chicago, IL., Boninger ML; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA., Ajiboye AB; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.; School of Medicine, Case Western Reserve University, Cleveland, OH.; Louis Stokes Cleveland VA Medical Center, Cleveland, OH., Graczyk EL; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH.; School of Medicine, Case Western Reserve University, Cleveland, OH.; Louis Stokes Cleveland VA Medical Center, Cleveland, OH., Downey JE; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL., Collinger JL; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA., Hatsopoulos NG; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL.; Committee on Computational Neuroscience, University of Chicago, Chicago, IL.; Neuroscience Institute, University of Chicago, Chicago, IL., Gaunt RA; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA., Bensmaia SJ; Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL.; Committee on Computational Neuroscience, University of Chicago, Chicago, IL.; Neuroscience Institute, University of Chicago, Chicago, IL.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 15. Date of Electronic Publication: 2023 Jul 15.
DOI: 10.1101/2023.06.23.545425
Abstrakt: When we interact with objects, we rely on signals from the hand that convey information about the object and our interaction with it. A basic feature of these interactions, the locations of contacts between the hand and object, is often only available via the sense of touch. Information about locations of contact between a brain-controlled bionic hand and an object can be signaled via intracortical microstimulation (ICMS) of somatosensory cortex (S1), which evokes touch sensations that are localized to a specific patch of skin. To provide intuitive location information, tactile sensors on the robotic hand drive ICMS through electrodes that evoke sensations at skin locations matching sensor locations. This approach requires that ICMS-evoked sensations be focal, stable, and distributed over the hand. To systematically investigate the localization of ICMS-evoked sensations, we analyzed the projected fields (PFs) of ICMS-evoked sensations - their location and spatial extent - from reports obtained over multiple years from three participants implanted with microelectrode arrays in S1. First, we found that PFs vary widely in their size across electrodes, are highly stable within electrode, are distributed over large swaths of each participant's hand, and increase in size as the amplitude or frequency of ICMS increases. Second, while PF locations match the locations of the receptive fields (RFs) of the neurons near the stimulating electrode, PFs tend to be subsumed by the corresponding RFs. Third, multi-channel stimulation gives rise to a PF that reflects the conjunction of the PFs of the component channels. By stimulating through electrodes with largely overlapping PFs, then, we can evoke a sensation that is experienced primarily at the intersection of the component PFs. To assess the functional consequence of this phenomenon, we implemented multichannel ICMS-based feedback in a bionic hand and demonstrated that the resulting sensations are more localizable than are those evoked via single-channel ICMS.
Databáze: MEDLINE