Mueller-matrix imaging polarimetry elevated by wavelet decomposition and polarization-singular processing for analysis of specific cancerous tissue pathology.
| Autor: | Sdobnov A; University of Oulu, Opto-Electronics and Measurement Techniques, Oulu, Finland., Ushenko VA; Chernivtsi National University, Optics and Publishing Department, Chernivtsi, Ukraine., Trifonyuk L; Rivne State Medical Center, Rivne, Ukraine., Bakun O; Chernivtsi National University, Optics and Publishing Department, Chernivtsi, Ukraine., Garazdyuk M; Chernivtsi National University, Optics and Publishing Department, Chernivtsi, Ukraine., Soltys IV; Chernivtsi National University, Optics and Publishing Department, Chernivtsi, Ukraine., Dubolazov O; Chernivtsi National University, Optics and Publishing Department, Chernivtsi, Ukraine., Ushenko OG; Chernivtsi National University, Optics and Publishing Department, Chernivtsi, Ukraine.; Zhejiang University, Taizhou Research Institute, College of Electrical Engineering, Hangzhou, China., Ushenko YA; Chernivtsi National University, Optics and Publishing Department, Chernivtsi, Ukraine., Bykov A; University of Oulu, Opto-Electronics and Measurement Techniques, Oulu, Finland., Meglinski I; University of Oulu, Opto-Electronics and Measurement Techniques, Oulu, Finland.; Aston University, College of Engineering and Physical Sciences, Birmingham, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of biomedical optics [J Biomed Opt] 2023 Oct; Vol. 28 (10), pp. 102903. Date of Electronic Publication: 2023 Jul 08. |
| DOI: | 10.1117/1.JBO.28.10.102903 |
| Abstrakt: | Significance: Mueller-matrix polarimetry is a powerful method allowing for the visualization of malformations in biological tissues and quantitative evaluation of alterations associated with the progression of various diseases. This approach, in fact, is limited in observation of spatial localization and scale-selective changes in the poly-crystalline compound of tissue samples. Aim: We aimed to improve the Mueller-matrix polarimetry approach by implementing the wavelet decomposition accompanied with the polarization-singular processing for express differential diagnosis of local changes in the poly-crystalline structure of tissue samples with various pathology. Approach: Mueller-matrix maps obtained experimentally in transmitted mode are processed utilizing a combination of a topological singular polarization approach and scale-selective wavelet analysis for quantitative assessment of the adenoma and carcinoma histological sections of the prostate tissues. Results: A relationship between the characteristic values of the Mueller-matrix elements and singular states of linear and circular polarization is established within the framework of the phase anisotropy phenomenological model in terms of linear birefringence. A robust method for expedited (up to ∼ 15 min ) polarimetric-based differential diagnosis of local variations in the poly-crystalline structure of tissue samples containing various pathology abnormalities is introduced. Conclusions: The benign and malignant states of the prostate tissue are identified and assessed quantitatively with a superior accuracy provided by the developed Mueller-matrix polarimetry approach. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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