| Autor: |
Belay A; Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia.; Food Science and Nutrition Research Directorate, Ethiopian Public Health Institute, Gulele Sub City, Addis Ababa, Ethiopia., Joy EJM; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Lark RM; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, UK., Ander EL; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, UK., Young SD; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, UK., Bailey EH; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, UK., Broadley MR; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, UK.; Rothamsted Research, West Common, Harpenden, Hertfordshire, UK., Gashu D; Center for Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia. |
| Abstrakt: |
Anaemia is characterised by low hemoglobin (Hb) concentration. Despite being a public health concern in Ethiopia, the role of micronutrients and non-nutritional factors as a determinant of Hb concentrations has been inadequately explored. This study focused on the assessment of serum micronutrient and Hb concentrations and a range of non-nutritional factors, to evaluate their associations with the risk of anaemia among the Ethiopian population ( n 2046). It also explored the mediation effect of Zn on the relation between se and Hb. Bivariate and multivariate regression analyses were performed to identify the relationship between serum micronutrients concentration, inflammation biomarkers, nutritional status, presence of parasitic infection and socio-demographic factors with Hb concentration ( n 2046). Sobel-Goodman test was applied to investigate the mediation of Zn on relations between serum se and Hb. In total, 18·6 % of participants were anaemic, 5·8 % had iron deficiency (ID), 2·6 % had ID anaemia and 0·6 % had tissue ID. Younger age, household head illiteracy and low serum concentrations of ferritin, Co, Cu and folate were associated with anaemia. Serum se had an indirect effect that was mediated by Zn, with a significant effect of se on Zn ( P < 0·001) and Zn on Hb ( P < 0·001). The findings of this study suggest the need for designing a multi-sectorial intervention to address anaemia based on demographic group. |
