Calreticulin: Endoplasmic reticulum Ca 2+ gatekeeper.

Autor: Michalak M; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Jazyk: angličtina
Zdroj: Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Mar; Vol. 28 (5), pp. e17839. Date of Electronic Publication: 2023 Jul 09.
DOI: 10.1111/jcmm.17839
Abstrakt: Endoplasmic reticulum (ER) luminal Ca 2+ is vital for the function of the ER and regulates many cellular processes. Calreticulin is a highly conserved, ER-resident Ca 2+ binding protein and lectin-like chaperone. Over four decades of studying calreticulin demonstrate that this protein plays a crucial role in maintaining Ca 2+ supply under different physiological conditions, in managing access to Ca 2+ and how Ca 2+ is used depending on the environmental events and in making sure that Ca 2+ is not misused. Calreticulin plays a role of ER luminal Ca 2+ sensor to manage Ca 2+ -dependent ER luminal events including maintaining interaction with its partners, Ca 2+ handling molecules, substrates and stress sensors. The protein is strategically positioned in the lumen of the ER from where the protein manages access to and distribution of Ca 2+ for many cellular Ca 2+ -signalling events. The importance of calreticulin Ca 2+ pool extends beyond the ER and includes influence of cellular processes involved in many aspects of cellular pathophysiology. Abnormal handling of the ER Ca 2+ contributes to many pathologies from heart failure to neurodegeneration and metabolic diseases.
(© 2023 The Author. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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