Targeting cytokine storm as the potential anti-viral therapy: Implications in regulating SARS-CoV-2 pathogenicity.

Autor: Maity S; Department of Biotechnology, REVA University, Bengaluru 560064, Karnataka, India., Santra A; Department of Biochemistry, Indian Academy Degree College, Bengaluru 560 043, India., Hebbani AV; Department of Biochemistry, Indian Academy Degree College, Bengaluru 560 043, India., Pulakuntla S; Department of Biotechnology, REVA University, Bengaluru 560064, Karnataka, India., Chatterjee A; Department of Biotechnology, REVA University, Bengaluru 560064, Karnataka, India., Badri KR; Department of Pharmacology and Toxicology, Cardiovascular Research Institute, Morehouse School of Medicine, GA, Atlanta 30310, USA; Clinical Analytical Chemistry Laboratory, COVID-19 Testing Laboratory, Morehouse School of Medicine, GA, Atlanta 30310, USA. Electronic address: kbadri@msm.edu., Damodara Reddy V; Department of Biotechnology, REVA University, Bengaluru 560064, Karnataka, India. Electronic address: damodara.reddyv@reva.edu.in.
Jazyk: angličtina
Zdroj: Gene [Gene] 2023 Sep 25; Vol. 881, pp. 147612. Date of Electronic Publication: 2023 Jul 08.
DOI: 10.1016/j.gene.2023.147612
Abstrakt: The latest global pandemic corona virus disease - 2019 (COVID-19) caused by the virus SARS-CoV-2 is still a matter of worrying concern both for the scientific communities and health care organizations. COVID-19 disease is proved to be a highly contagious disease transmitted through respiratory droplets and even close contact with affected individuals. COVID-19 disease is also understood to exhibit diverse symptoms of ranging severities i.e., from mild fatigue to death. Affected individuals' susceptibility to induce immunologic dysregulation phenomena termed 'cytokine storm' seems to be playing the damaging role of escalating the disease manifestation from mild to severe. Cytokine storm in patients with severe symptoms is understood to be characterized by enhanced serum levels of many cytokines including interleukin-1β, interleukin-6, IP-10/CXCL10, TNF, interferon-γ, MIP-1α, MIP-1β and VEGF. Since cytokine production in general is the most important antiviral defense response, understanding the COVID-19 associated cytokine storm in particular and differentiating it from the regular cytokine production response becomes crucial in developing an effective therapeutic strategy.This review focuses on the potential targeting of COVID-19 associated cytokine storm and its challenges.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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