Influence of the Dose and Frequency of Administration of Tramadol on Analgesia, Hematological, Biochemical Parameters, and Oxidative Status of Cats Undergoing Ovariohysterectomy.

Autor: Schimites PI; Department of Small Animal Clinics, Graduate Program in Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address: paulinhaschi@gmail.com., Martins LR; Department of Small Animal Clinics, Graduate Program in Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Teixeira LG; Department of Small Animal Clinics, Graduate Program in Veterinary Science, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Tomio J; Department of Small Animal Clinics, Graduate Program in Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Segat H; Department of Small Animal Clinics, Veterinary Medicine College, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Baccin P; Department of Small Animal Clinics, Veterinary Medicine College, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Lisboa APB; Department of Small Animal Clinics, Veterinary Medicine College, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., de Andrade CM; Toxicological biochemistry, Graduate Program in Biological Sciences: Toxicological biochemistry, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., de Oliveira JS; Toxicological biochemistry, Graduate Program in Biological Sciences: Toxicological biochemistry, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Dornelles GL; Department of Small Animal Clinics, Graduate Program in Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Engelmann AM; Department of Small Animal Clinics, Graduate Program in Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., de Oliveira RB; Department of Small Animal Clinics, Graduate Program in Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Benetti LC; Department of Small Animal Clinics, Veterinary Medicine College, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Soares AV; Department of Small Animal Clinics, Graduate Program in Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Jazyk: angličtina
Zdroj: Topics in companion animal medicine [Top Companion Anim Med] 2023 Jul-Aug; Vol. 55, pp. 100801. Date of Electronic Publication: 2023 Jul 07.
DOI: 10.1016/j.tcam.2023.100801
Abstrakt: This study aimed to evaluate the effects of the repeated administration of tramadol subcutaneously on postoperative analgesia, liver, kidneys, and oxidative status in the postoperative period of cats undergoing ovariohysterectomy. Thirty-seven cats were randomly assigned to 5 groups, according to the postoperative analgesic treatment: NaCl 0.9%, GC; tramadol at 2 mg/kg, T2B (q12h) and T2T (q8h); or 4 mg/kg, T4B (q12h) and T4T (q8h). Oxidative status was assessed at baseline, 12 hours and 24 hours after the final administration of tramadol by the activity of superoxide dismutase (SOD), catalase (CAT), myeloperoxidase (MPO), butyrylcholinesterase (BuChE), and lipoperoxidation (MDA). Total blood count, serum biochemistry and urinalysis were compared between baseline and 12 hours posttramadol. Postoperative pain was evaluated by applying the Glasgow Feline Composite Measure Pain Scale at baseline, 3 (T3), 6 (T6), 8 (T8), 12 (T12), 24 (T24) e 36 (T36) hours after extubation. No side effects were observed. Tramadol increased SOD activity while CAT varied among groups in all time points but not over time. MDA levels increased from baseline to 12 hours in all groups but T4T. MPO activity decreased from baseline to 24 hours in some groups, including GC. Creatinine and phosphatase alkaline decreased in T2T, T4B, and T4T at 12 hours. Higher pain scores were observed from T3 to T8, except for GC. Rescue analgesia was administered only at T3. No difference in pain scores was observed from T8 onwards. Based on the findings, it is suggested that tramadol at 2 mg/kg every 8 hours is recommended for postoperative analgesia of cats undergoing ovariohysterectomy.
Competing Interests: Declaration of Competing Interest None of the authors of this article has a financial or personal relationship with other people or organizations that may influence the content of the article, declaring any potential conflict of interest.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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