Fracture risk among patients with cancer compared to individuals without cancer: a population-based study.

Autor: Gong IY; Department of Medicine, University of Toronto, Toronto, ON, Canada., Chan KKW; Department of Medicine, University of Toronto, Toronto, ON, Canada.; ICES, Toronto, ON, Canada.; Odette Cancer Centre, Sunnybrook Health Sciences Center, Toronto, ON, Canada., Lipscombe LL; Department of Medicine, University of Toronto, Toronto, ON, Canada.; ICES, Toronto, ON, Canada.; Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada., Cheung MC; Department of Medicine, University of Toronto, Toronto, ON, Canada.; ICES, Toronto, ON, Canada.; Odette Cancer Centre, Sunnybrook Health Sciences Center, Toronto, ON, Canada., Mozessohn L; Department of Medicine, University of Toronto, Toronto, ON, Canada. lee.mozessohn@sunnybrook.ca.; ICES, Toronto, ON, Canada. lee.mozessohn@sunnybrook.ca.; Odette Cancer Centre, Sunnybrook Health Sciences Center, Toronto, ON, Canada. lee.mozessohn@sunnybrook.ca.
Jazyk: angličtina
Zdroj: British journal of cancer [Br J Cancer] 2023 Sep; Vol. 129 (4), pp. 665-671. Date of Electronic Publication: 2023 Jul 08.
DOI: 10.1038/s41416-023-02353-4
Abstrakt: Background: Patients with cancer may be at increased risk of osteoporosis and fracture; however, gaps exist in the existing literature and the association between cancer and fracture requires further examination.
Methods: We conducted a population-based cohort study of Ontario patients with cancer (breast, prostate, lung, gastrointestinal, haematologic) diagnosed between January 2007 to December 2018 and 1:1 matched non-cancer controls. The primary outcome was incident fracture (end of follow-up December 2019). Multivariable Cox regression analysis was used to estimate the relative fracture risk with sensitivity analysis accounting for competing risk of death.
Results: Among 172,963 cancer patients with non-cancer controls, 70.6% of patients with cancer were <65 years old, 58% were female, and 9375 and 8141 fracture events were observed in the cancer and non-cancer group, respectively (median follow-up 6.5 years). Compared to non-cancer controls, patients with cancer had higher risk of fracture (adjusted HR [aHR] 1.10, 95% CI 1.07-1.14, p < 0.0001), which was also observed for both solid (aHR 1.09, 95% CI 1.05-1.13, p < 0.0001) and haematologic cancers (aHR 1.20, 95% CI 1.10-1.31, p < 0.0001). Sensitivity analysis accounting for competing risk of death did not change these findings.
Conclusions: Our study indicates that patients with cancer are at modest risk of fractures compared to non-cancer controls.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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