Arousal deregulation in the co-shaping of neuropsychological dysfunction in frontal and mesial temporal lobe epilepsy.

Autor: Poprelka K; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece. Electronic address: katerinapop@med.uoa.gr., Patrikelis P; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece; Laboratory of Cognitive Neuroscience, Department of Psychology, Aristotle University of Thessaloniki, Greece., Takousi M; School of Health Sciences, Metropolitan College, Athens, Greece., Messinis L; Laboratory of Cognitive Neuroscience, Department of Psychology, Aristotle University of Thessaloniki, Greece., Fasilis T; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece., Margariti S; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece., Ntinopoulou E; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece., Verentzioti A; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece., Stefanatou M; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece., Alexoudi A; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece., Korfias S; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece., Zalonis I; Aeginition Hospital, Medical School, National & Kapodistrian University of Athens, Neuropsychological Laboratory, 1st Department of Neurology, Greece., Gatzonis S; 1st Department of Neurosurgery, National & Kapodistrian University of Athens, Greece.
Jazyk: angličtina
Zdroj: Epilepsy research [Epilepsy Res] 2023 Aug; Vol. 194, pp. 107189. Date of Electronic Publication: 2023 Jul 04.
DOI: 10.1016/j.eplepsyres.2023.107189
Abstrakt: Objective: Our work aims to investigate the role of physiological arousal in the expression of neuropsychological deficits in frontal lobe epilepsy (FLE) and mesial temporal lobe epilepsy (mTLE), by drawing on the Lurian theory of brain function.
Methods: For this study a total of 43 patients with focal onset epilepsy has been taken; twenty-four patients with FLE, 19 patients with mTLE and 26 healthy controls, all matched for age and education. Participants underwent a comprehensive neuropsychological assessment including various cognitive domains, such as attention, episodic memory, speed of information processing, response inhibition and mental flexibility, working memory, verbal fluency (phonological & semantic).
Results: There were no significant differences between FLE and mTLE patients in terms of neuropsychological performance. However, both FLE and mTLE patients showed significantly worse performance in several cognitive domains than HCs. The results seem to support our hypothesis that aberrant physiological arousal, as reflected in patients' worse performance in vigilance and attention, response inhibition, and processing speed, along with other disease-specific variables, may co-determine neuropsychological dysfunction and/or impairment in both FLE and mTLE.
Conclusion: Identifying a differential arousal-related neuropsychological affection in FLE and mTLE, among the known deleterious effects of the functional deficit zone and other disease-related variables, may further our understanding of the underlying cognitive-pathophysiological mechanisms in focal epilepsy syndromes.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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