Ascorbic Acid for Methemoglobinemia Treatment: A Case Report and Literature Review.
| Autor: | Keats KR; Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA., Robinson R; Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA., Patel M; Department of Internal Medicine, Augusta University Medical Center, Augusta, GA, USA., Wallace A; Department of Internal Medicine, Augusta University Medical Center, Augusta, GA, USA., Albrecht S; Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pharmacy practice [J Pharm Pract] 2024 Aug; Vol. 37 (4), pp. 1015-1020. Date of Electronic Publication: 2023 Jul 08. |
| DOI: | 10.1177/08971900231188834 |
| Abstrakt: | Purpose: Ascorbic acid has been proposed as an alternative treatment for methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, its efficacy has never been compared to that of methylene blue given the inability of patients with G6PD deficiency to receive methylene blue. We present a case of methemoglobinemia treated with ascorbic acid in a patient without G6PD deficiency who had previously received methylene blue. Summary: A 66-year-old male was treated for methemoglobinemia deemed to be secondary to benzocaine throat spray. He received intravenous (IV) methylene blue but had a severe reaction: diaphoresis, lightheadedness, and hypotension. The infusion was stopped prior to completion. Approximately 6 days later he presented with methemoglobinemia following an additional overconsumption of benzocaine and was treated with ascorbic acid. In both instances his methemoglobin levels were >30% on arterial blood gas on admission and decreased to 6.5% and 7.8%, respectively, after administration of methylene blue and ascorbic acid. Conclusion: Ascorbic acid had a similar effect on decreasing the concentration of methemoglobin compared to methylene blue. Further research into use of ascorbic acid as a recommended agent for treatment of methemoglobinemia is warranted. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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