Mammalian aging driven by transcription going awry.

Autor: McCauley BS; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA., Dang W; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA. Electronic address: weiwei.dang@bcm.edu.
Jazyk: angličtina
Zdroj: Trends in genetics : TIG [Trends Genet] 2023 Oct; Vol. 39 (10), pp. 715-716. Date of Electronic Publication: 2023 Jul 05.
DOI: 10.1016/j.tig.2023.06.006
Abstrakt: The mechanisms that underlie increased cryptic transcription during senescence and aging have been poorly understood. Sen et al. recently identified cryptic transcription start sites (cTSSs) and chromatin state changes that may contribute to cTSS activation in mammals. Their results indicate that enhancer-promoter conversion may drive cryptic transcription in senescence.
Competing Interests: Declaration of interests The authors have no conflicts of interests to declare.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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