Aldo-keto reductase family 1 member B10 is regulated by nucleos(t)ide analogues for chronic hepatitis B.

Autor: Orita N; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Kawaguchi K; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. Electronic address: kawaguchi@m-kanazawa.jp., Honda M; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Shimode T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Hayakawa N; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Terashima T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Komura T; Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan., Nishikawa M; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Horii R; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Nio K; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Shimakami T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Takatori H; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Arai K; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Sakai Y; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Mizukoshi E; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Kaneko S; Department of Information-Based Medicine Development, Kanazawa University Graduate School of Medicine, Kanazawa, Japan., Kagaya T; Department of Gastroenterology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Sep 24; Vol. 674, pp. 133-139. Date of Electronic Publication: 2023 Jul 01.
DOI: 10.1016/j.bbrc.2023.06.093
Abstrakt: The number of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients persists even under nucleos(t)ide analogues (NAs) treatment. Aldo-keto reductase family 1 member B10 (AKR1B10) expression has been reported in advanced chronic liver diseases as well as cancer tissues. We observed an association between related to HCC incidence and serum AKR1B10 by analyzing patients under treatment with NAs. Serum AKR1B10 levels measured by ELISA were higher in HCC cases under NA treatment compared with non-HCC cases and were associated with lamivudine- and adefovir pivoxil-, but not entecavir- or tenofovir alafenamide-treated cases. The latter drugs did not increase AKR1B10 values even in HCC cases, suggesting that they influence the reduction of AKR1B10 in any cases. This analysis was supported by in-vitro examination, which showed reduced AKR1B10 expression by entecavir and tenofovir via immunofluorescence staining. In conclusion there was a relationship between HBV-related HCC incidence and AKR1B10 under nucleos(t)ide analogues, especially in the use of lamivudine and adefovir pivoxil, but entecavir and tenofovir had suppressive effects of AKR1B10.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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