Synergistic effects of low-dose arsenic and N-methyl-N'-nitro-N-nitrosoguanidine co-exposure by altering gut microbiota and intestinal metabolic profile in rats.

Autor: Wang K; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Lin X; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Wang T; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Zhang X; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Cheng W; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Xu F; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Wang L; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Li B; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Wang M; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Wang W; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Zhang M; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Ding S; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Jin G; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Zhu Y; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Yang W; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China., Hu A; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China. Electronic address: huanla@ahmu.edu.cn., Zhao Q; Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, China. Electronic address: qihong@ahmu.edu.cn.
Jazyk: angličtina
Zdroj: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2023 Sep 15; Vol. 263, pp. 115195. Date of Electronic Publication: 2023 Jul 05.
DOI: 10.1016/j.ecoenv.2023.115195
Abstrakt: Biological organisms are exposed to low-dose arsenic or N-nitro compounds (NOCs) alone or in combination worldwide, especially in areas with high cancer prevalence through drinking water or food exposure; however, information on their combined exposure effects is limited. Here, we conducted an in-depth study of the effects on the gut microbiota, metabolomics, and signaling pathways using rat models exposed to arsenic or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), one of the most active carcinogenic NOCs, separately or in combination with metabolomics and high-throughput sequencing. Compared to exposure alone, combined exposure to arsenic and MNNG exacerbated damage to gastric tissue morphology, interfered with intestinal microflora and substance metabolism, and exerted a stronger carcinogenic effect. This may be related to intestinal microbiota disorders, including Dyella, Oscillibacter, Myroides, and metabolic pathways such as glycine, serine, and threonine metabolism, arginine biosynthesis, central carbon metabolism in cancer, and purine and pyrimidine metabolism, thereby enhancing the cancer-causing effects of gonadotrophin-releasing hormone (GnRH), P53, and Wnt signaling pathways.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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