Amniotic Membrane Transplantation in the Management of Corneal Ulceration Following Infectious Keratitis.

Autor:	Lamas-Francis D; Department of Ophthalmology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain., Navarro D; Department of Microbiology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain., Moreno C; Department of Ophthalmology, University Hospital of Ourense, Ourense, Spain., de-Rojas V; Department of Ophthalmology, University Hospital of A Coruña, A Coruña, Spain., Mansilla R; Department of Ophthalmology, University Hospital of Vigo, Vigo, Spain., Dios E; Department of Ophthalmology, University Hospital of Pontevedra, Pontevedra, Spain., Rigueiro J; Department of Ophthalmology, University Hospital Lucus Augusti, Lugo, Spain., Álvarez D; Department of Ophthalmology, University Hospital of Ferrol, Ferrol, Spain., Crego P; Department of Ophthalmology, Hospital Público da Mariña, Burela, Spain., Rodríguez-Ares T; Department of Ophthalmology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain., Touriño R; Department of Ophthalmology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Jazyk:	angličtina
Zdroj:	Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Sep; Vol. 32 (7), pp. 1261-1267. Date of Electronic Publication: 2023 Jul 07.
DOI:	10.1080/09273948.2023.2228901
Abstrakt:	Purpose: To report on the outcomes of amniotic membrane transplantation (AMT) for corneal ulceration following infectious keratitis. Method: In this retrospective cohort study of 654 patients with culture-proven infectious keratitis from 8 hospitals in Galicia (Spain), a total of 43 eyes of 43 patients (6.6%) underwent AMT for postinfectious corneal ulceration. The indications for AMT were sterile persistent epithelial defects, severe corneal thinning or perforation. Results: AMT was successful in 62.8% of cases, with 37.2% requiring an additional surgery. Median time to healing was 40.0 days (IQR 24.2-101.7 days) and final BCVA was lower than baseline ( p  = 0.001). Ulcers were large (>3 mm) in 55.8% of cases. Previous herpetic keratitis and topical steroid use were more common in patients who received AMT ( p  < 0.001). 49 microorganisms (43 bacteria and 6 fungi) were isolated. Conclusions: AMT is a therapeutic option for complications following infectious keratitis, which present with a sterile persistent epithelial defect, significant corneal thinning or perforation.
Databáze:	MEDLINE
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