Thermoreversible Gel Formulation for the Intranasal Delivery of Salmon Calcitonin and Comparison Studies of In Vivo Bioavailability.
| Autor: | Alparslan AL; İstinye University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İstanbul, Türkiye., Yıldız Türkyılmaz G; Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İzmir, Türkiye., Kozacı LD; Ankara Yıldırım Beyazıt University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Türkiye., Karasulu E; Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İzmir, Türkiye. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2023 Jul 07; Vol. 20 (3), pp. 127-140. |
| DOI: | 10.4274/tjps.galenos.2022.09482 |
| Abstrakt: | Objectives: We developed original thermoreversible (sol-gel) formulations of salmon calcitonin (sCT) for nasal applications. The sol-gel has been compared with commercial intranasal sprays in vitro and in vivo studies. The aim of studying sol-gel form is to arrange the viscosity of formulations for a reversible adequate fluidity at different temperatures. This situation may facilitate the use of drugs as sprays and increase the bioadhesive ability to mucosa. Materials and Methods: Characterization of optimum formulations was studied. Validated analytical assays determined the number of sCT. An approximately equal number of commercial and sol-gel dosages were sprayed into the nostrils of the rabbits. Blood samples were collected from the ear veins of rabbits and determined by enzyme immunoassay plates. These plates were evaluated by Thermo Labsystem Multiscan Spectrum at 450 nm. Thanks to Winnonlin 5.2, pharmacokinetic data were evaluated by a non-compartmental method. Results: The absolute bioavailability of the formulation at pH 4 and the commercial product (CP) was compared by evaluating the primary pharmacokinetic data area under the curve 0→t Conclusion: In vivo pharmacokinetic data of sol-gel formulation with pH 3 showed significantly higher volume of distribution parameter than the CP (111167>35408). It is thought that the formulation adhered to the nasal mucosa releases sCT slowly and less. Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors. (©Copyright 2023 by Turkish Pharmacists' Association / Turkish Journal of Pharmaceutical Sciences published by Galenos Publishing House.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|