Wolbachia genetically interacts with the bag of marbles germline stem cell gene in male D. melanogaster .
| Autor: | Wenzel M; Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States., Aquadro CF; Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States. |
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| Jazyk: | angličtina |
| Zdroj: | MicroPublication biology [MicroPubl Biol] 2023 May 25; Vol. 2023. Date of Electronic Publication: 2023 May 25 (Print Publication: 2023). |
| DOI: | 10.17912/micropub.biology.000845 |
| Abstrakt: | The bacterial endosymbiont Wolbachia manipulates reproduction of its arthropod hosts to promote its own maternal vertical transmission. In female D. melanogaster , Wolbachia has been shown to genetically interact with three key reproductive genes ( bag of marbles ( bam ) , Sex-lethal, and mei-P26) , as it rescues the reduced female fertility or fecundity phenotype seen in partial loss-of-function mutants of these genes . Here, we show that Wolbachia also partially rescues male fertility in D. melanogaster carrying a new, largely sterile bam allele when in a bam null genetic background. This finding shows that the molecular mechanism of Wolbachia 's influence on its hosts' reproduction involves interaction with genes in males as well as females, at least in D. melanogaster . Competing Interests: The authors declare that there are no conflicts of interest present. (Copyright: © 2023 by the authors.) |
| Databáze: | MEDLINE |
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