Clinical and Echocardiographic Correlates of Iron Status in Chronic Heart Failure Patients: A Cross-Sectional Descriptive Study.
| Autor: | Amaechi UM; Internal Medicine, Lagos University Teaching Hospital, Lagos, NGA., Chukwudum E; General Practice, Love Your Menses, Inc., Boston, USA., Aiwuyo HO; Internal Medicine, Brookdale University Hospital and Medical Center, New York, USA., Ilerhunmwuwa N; Internal Medicine, Brookdale Hospital Medical Center, New York, USA., Osarenkhoe JO; Medicine and Surgery, Igbinedion University Teaching Hospital, Benin City, NGA., Kweki AG; Internal Medicine and Cardiology, Colchester Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester, GBR., Onuwaje OE; Cardiology and Acute Medicine, Royal Blackburn Teaching Hospital, Blackburn, GBR., Obilahi JO; General Medicine, Maidstone General Hospital, Kent, GBR., Irabor GI; Pathology, Saba University School of Medicine, Saba, NLD., Attuquayefio S; Internal Medicine, Korle Bu Teaching Hospital, Accra, GHA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Jun 05; Vol. 15 (6), pp. e39998. Date of Electronic Publication: 2023 Jun 05 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.39998 |
| Abstrakt: | Background: Chronic heart failure (HF) is one of the conditions commonly seen in the medical outpatient departments, and iron deficiency (ID) has been reported as the commonest nutritional deficiency in these patients. The presence of ID may interfere with the clinical parameters of chronic HF. The relationship between iron status and chronic HF needs more attention and should be given more consideration in the evaluation of patients with chronic HF. Aim: The aim of the study was to determine the relationship, if any, between iron status and clinical/echocardiographic variables in chronic HF. Methods and Materials: A cross-sectional descriptive study was carried out at the Lagos University Teaching Hospital (LUTH), Nigeria, where 88 patients with chronic HF were recruited to participate in this study. The participants underwent clinical and laboratory assessments. Iron status was assessed with full blood count parameters; serum ferritin and transferrin saturation (Tsat) and its relationship with clinical parameters among these participants were also studied. Results: No correlations existed between the duration of chronic HF and iron status when compared using Tsat. However, a significant weak negative correlation was observed between the duration of HF and the serum ferritin levels. The clinical characteristics of the HF participants with and without ID were compared. There was no significant difference in the frequency of prior hospitalization in both groups. However, a higher proportion of participants with severe HF (New York Heart Association (NYHA) classes III/IV) (n = 14; 46.7%) were iron-deficient compared to those with moderate chronic HF (NYHA II) (n = 11; 36.7%). This relationship was statistically significant. Left ventricular ejection fraction (LVEF) was similar in the iron-deficient and iron-replete groups (using serum ferritin or Tsat) both when compared as means and when compared after categorizing LVEF as HF with preserved ejection fraction (HFpEF) vs HF with reduced ejection fraction (HFrEF). There was no statistically significant correlation between the severity of ID and LVEF. Conclusion: A spectrum of clinical changes occurs in patients with chronic HF. ID can make these changes more profound and the condition less amenable to standard HF treatments. These patients may therefore benefit from further evaluation for this nutritional deficiency. Laboratory measurements including Tsat and serum ferritin may help in further assessment of select patients with worse and/or non-responsive clinical parameters. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Amaechi et al.) |
| Databáze: | MEDLINE |
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