Network Localization of Spontaneous Confabulation.

Autor:	Bateman JR; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, N.C., and Mental Illness Research, Education and Clinical Center, Salisbury VA Medical Center, Salisbury, N.C. (Bateman); Department of Neurology and Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston (Ferguson, Fox); Behavioral Neurology Section, Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora (Anderson, Arciniegas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Rotman Research Institute at Baycrest Health Sciences and Department of Psychology, University of Toronto, Toronto (Gilboa); Department of Neurology, Virginia Commonwealth University, Richmond, Va. (Berman)., Ferguson MA; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, N.C., and Mental Illness Research, Education and Clinical Center, Salisbury VA Medical Center, Salisbury, N.C. (Bateman); Department of Neurology and Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston (Ferguson, Fox); Behavioral Neurology Section, Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora (Anderson, Arciniegas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Rotman Research Institute at Baycrest Health Sciences and Department of Psychology, University of Toronto, Toronto (Gilboa); Department of Neurology, Virginia Commonwealth University, Richmond, Va. (Berman)., Anderson CA; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, N.C., and Mental Illness Research, Education and Clinical Center, Salisbury VA Medical Center, Salisbury, N.C. (Bateman); Department of Neurology and Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston (Ferguson, Fox); Behavioral Neurology Section, Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora (Anderson, Arciniegas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Rotman Research Institute at Baycrest Health Sciences and Department of Psychology, University of Toronto, Toronto (Gilboa); Department of Neurology, Virginia Commonwealth University, Richmond, Va. (Berman)., Arciniegas DB; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, N.C., and Mental Illness Research, Education and Clinical Center, Salisbury VA Medical Center, Salisbury, N.C. (Bateman); Department of Neurology and Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston (Ferguson, Fox); Behavioral Neurology Section, Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora (Anderson, Arciniegas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Rotman Research Institute at Baycrest Health Sciences and Department of Psychology, University of Toronto, Toronto (Gilboa); Department of Neurology, Virginia Commonwealth University, Richmond, Va. (Berman)., Gilboa A; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, N.C., and Mental Illness Research, Education and Clinical Center, Salisbury VA Medical Center, Salisbury, N.C. (Bateman); Department of Neurology and Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston (Ferguson, Fox); Behavioral Neurology Section, Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora (Anderson, Arciniegas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Rotman Research Institute at Baycrest Health Sciences and Department of Psychology, University of Toronto, Toronto (Gilboa); Department of Neurology, Virginia Commonwealth University, Richmond, Va. (Berman)., Berman BD; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, N.C., and Mental Illness Research, Education and Clinical Center, Salisbury VA Medical Center, Salisbury, N.C. (Bateman); Department of Neurology and Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston (Ferguson, Fox); Behavioral Neurology Section, Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora (Anderson, Arciniegas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Rotman Research Institute at Baycrest Health Sciences and Department of Psychology, University of Toronto, Toronto (Gilboa); Department of Neurology, Virginia Commonwealth University, Richmond, Va. (Berman)., Fox MD; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, N.C., and Mental Illness Research, Education and Clinical Center, Salisbury VA Medical Center, Salisbury, N.C. (Bateman); Department of Neurology and Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston (Ferguson, Fox); Behavioral Neurology Section, Department of Neurology, University of Colorado Anschutz Medical Campus, Aurora (Anderson, Arciniegas); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Arciniegas); Rotman Research Institute at Baycrest Health Sciences and Department of Psychology, University of Toronto, Toronto (Gilboa); Department of Neurology, Virginia Commonwealth University, Richmond, Va. (Berman).
Jazyk:	angličtina
Zdroj:	The Journal of neuropsychiatry and clinical neurosciences [J Neuropsychiatry Clin Neurosci] 2024 Winter; Vol. 36 (1), pp. 45-52. Date of Electronic Publication: 2023 Jul 07.
DOI:	10.1176/appi.neuropsych.20220160
Abstrakt:	Objective: Spontaneous confabulation is a symptom in which false memories are conveyed by the patient as true. The purpose of the study was to identify the neuroanatomical substrate of this complex symptom and evaluate the relationship to related symptoms, such as delusions and amnesia. Methods: Twenty-five lesion locations associated with spontaneous confabulation were identified in a systematic literature search. The network of brain regions functionally connected to each lesion location was identified with a large connectome database (N=1,000) and compared with networks derived from lesions associated with nonspecific (i.e., variable) symptoms (N=135), delusions (N=32), or amnesia (N=53). Results: Lesions associated with spontaneous confabulation occurred in multiple brain locations, but they were all part of a single functionally connected brain network. Specifically, 100% of lesions were connected to the mammillary bodies (familywise error rate [FWE]-corrected p<0.05). This connectivity was specific for lesions associated with confabulation compared with lesions associated with nonspecific symptoms or delusions (FWE-corrected p<0.05). Lesions associated with confabulation were more connected to the orbitofrontal cortex than those associated with amnesia (FWE-corrected p<0.05). Conclusions: Spontaneous confabulation maps to a common functionally connected brain network that partially overlaps, but is distinct from, networks associated with delusions or amnesia. These findings lend new insight into the neuroanatomical bases of spontaneous confabulation. Competing Interests: Dr. Bateman has received honoraria from the North Carolina Neurological Society and the South East Area Health Education Center and from Novo Nordisk for participation in educational activities. Dr. Berman has received honoraria from the International Parkinson and Movement Disorder Society. Dr. Fox serves as a consultant for Abbott, Boston Scientific, Magnus Medical, and Soterix Medical; and he owns intellectual property on using connectivity imaging to guide brain stimulation. The other authors report no financial relationships with commercial interests.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu