Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.

Autor: Murase S; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan.; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Sakitani N; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan.; Department of Cell Biology, National Cerebral and Cardiovascular Center, Suita, Japan., Maekawa T; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan., Yoshino D; Division of Advanced Applied Physics, Institute of Engineering, Tokyo University of Agriculture and Technology, Koganei, Japan., Takano K; Department of Rehabilitation for Brain Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan., Konno A; Department of Neurophysiology & Neural Repair, Gunma University Graduate School of Medicine, Maebashi, Japan., Hirai H; Department of Neurophysiology & Neural Repair, Gunma University Graduate School of Medicine, Maebashi, Japan., Saito T; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tanaka S; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Shinohara K; Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan., Kishi T; Department of Cardiology, Graduate School of Medicine, International University of Health and Welfare, Okawa, Japan., Yoshikawa Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Sakai T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Ayaori M; Tokorozawa Heart Center, Tokorozawa, Japan., Inanami H; Inanami Spine & Joint Hospital/Iwai Orthopaedic Medical Hospital, Iwai Medical Foundation, Tokyo, Japan., Tomiyasu K; Center of Sports Science and Health Promotion, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan., Takashima A; Department of Assistive Technology, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan., Ogata T; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan.; Department of Rehabilitation Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tsuchimochi H; Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Suita, Japan., Sato S; Department of Advanced Medical Technologies, National Cerebral and Cardiovascular Center, Suita, Japan., Saito S; Department of Medical Physics and Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Japan., Yoshino K; School of Biological and Environmental Sciences, Kwansei Gakuin University, Sanda, Japan., Matsuura Y; Department of Health and Sports, Niigata University of Health and Welfare, Niigata, Japan., Funamoto K; Institute of Fluid Science, Tohoku University, Sendai, Japan., Ochi H; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan., Shinohara M; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan., Nagao M; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan., Sawada Y; Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan. ys454-ind@umin.ac.jp.; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ys454-ind@umin.ac.jp.; Department of Cell Biology, National Cerebral and Cardiovascular Center, Suita, Japan. ys454-ind@umin.ac.jp.; Division of Advanced Applied Physics, Institute of Engineering, Tokyo University of Agriculture and Technology, Koganei, Japan. ys454-ind@umin.ac.jp.; Department of Clinical Research, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan. ys454-ind@umin.ac.jp.
Jazyk: angličtina
Zdroj: Nature biomedical engineering [Nat Biomed Eng] 2023 Nov; Vol. 7 (11), pp. 1350-1373. Date of Electronic Publication: 2023 Jul 06.
DOI: 10.1038/s41551-023-01061-x
Abstrakt: The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions mimicking mechanical accelerations experienced during fast walking, light jogging or treadmill running at a moderate velocity reduce the blood pressure of rats and human adults with hypertension. In hypertensive rats, shear stresses of less than 1 Pa resulting from interstitial-fluid flow induced by such passive head motions reduced the expression of the angiotensin II type-1 receptor in astrocytes in the rostral ventrolateral medulla, and the resulting antihypertensive effects were abrogated by hydrogel introduction that inhibited interstitial-fluid movement in the medulla. Our findings suggest that oscillatory mechanical interventions could be used to elicit antihypertensive effects.
(© 2023. The Author(s).)
Databáze: MEDLINE
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