Pulsed sonodynamic therapy of melanoma cancer cells using nanoparticles of and mesoporous platinum.

Autor:	Zahraie N; Nanomedicine and Nanobiology Research Center and Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Haghighi H; Nanomedicine and Nanobiology Research Center and Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Salehi F; Nanomedicine and Nanobiology Research Center and Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Daneshvar F; Nanomedicine and Nanobiology Research Center and Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Tamaddon P; Nanomedicine and Nanobiology Research Center and Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Sattarahmady N; Nanomedicine and Nanobiology Research Center and Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: sattarahmady@yahoo.com.
Jazyk:	angličtina
Zdroj:	Ultrasound in medicine & biology [Ultrasound Med Biol] 2023 Sep; Vol. 49 (9), pp. 2160-2168. Date of Electronic Publication: 2023 Jul 04.
DOI:	10.1016/j.ultrasmedbio.2023.06.011
Abstrakt:	Objective: Noble metal nanomaterials have been introduced as ideal sonosensitizers for sonodynamic therapy (SDT) of cancer. In this research, platinum nanoparticles (PtNPs) and mesoporous platinum (MPt) were first synthesized and then evaluated as novel sonosensitizers. Methods: Ultrasound waves were radiated at two different power densities and two different pulse ratios to develop a pulsed radiation route for SDT of the malignant melanoma cell line C540 (B16/F10). Fluorescence emission was recorded as an indicator of intracellular reactive oxygen generation during the treatment. Results: Platinum nanoparticles had an average diameter of 12 ± 7 nm and a zeta potential of -17.6 mV; also, MPt had a sponge-like and highly porous structure with a pore size <11 nm and a zeta potential of -39.5 mV. Both PtNPs and MPt, particularly the latter, enhanced the rate of inhibition of tumor cell growth on ultrasound radiation at an output power density of 1.0 W cm -2 and pulse ratio of 30% over 10 min without intensifying temperature. Conclusion: Use of the developed pulsed (rather than continuous) radiation in SDT and PtNPs or MPT, without hyperthermia, resulted in a new effective cancer treatment method based on the mechanisms of cavitation and/or ROS generation. Competing Interests: Conflict of interest The authors declare no competing interests. (Copyright © 2023 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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