Asymmetric Voltage Attenuation in Dendrites Can Enable Hierarchical Heterosynaptic Plasticity.
| Autor: | Moldwin T; Edmond and Lily Safra Center for Brain Sciences Toviah.moldwin@mail.huji.ac.il., Kalmenson M; Department of Neurobiology, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel., Segev I; Edmond and Lily Safra Center for Brain Sciences.; Department of Neurobiology, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel. |
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| Jazyk: | angličtina |
| Zdroj: | ENeuro [eNeuro] 2023 Jul 17; Vol. 10 (7). Date of Electronic Publication: 2023 Jul 17 (Print Publication: 2023). |
| DOI: | 10.1523/ENEURO.0014-23.2023 |
| Abstrakt: | Long-term synaptic plasticity is mediated via cytosolic calcium concentrations ([Ca 2+ ]). Using a synaptic model that implements calcium-based long-term plasticity via two sources of Ca 2+ - NMDA receptors and voltage-gated calcium channels (VGCCs) - we show in dendritic cable simulations that the interplay between these two calcium sources can result in a diverse array of heterosynaptic effects. When spatially clustered synaptic input produces a local NMDA spike, the resulting dendritic depolarization can activate VGCCs at nonactivated spines, resulting in heterosynaptic plasticity. NMDA spike activation at a given dendritic location will tend to depolarize dendritic regions that are located distally to the input site more than dendritic sites that are proximal to it. This asymmetry can produce a hierarchical effect in branching dendrites, where an NMDA spike at a proximal branch can induce heterosynaptic plasticity primarily at branches that are distal to it. We also explored how simultaneously activated synaptic clusters located at different dendritic locations synergistically affect the plasticity at the active synapses, as well as the heterosynaptic plasticity of an inactive synapse "sandwiched" between them. We conclude that the inherent electrical asymmetry of dendritic trees enables sophisticated schemes for spatially targeted supervision of heterosynaptic plasticity. Competing Interests: The authors declare no competing financial interests. (Copyright © 2023 Moldwin et al.) |
| Databáze: | MEDLINE |
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