Neuroprotective effect of quercetin nanoparticles: A possible prophylactic effect in cerebellar neurodegenerative disorders.

Autor: El-Tahawy NFG; Department of Histology and Cell Biology, Minia University, Faculty of Medicine, Minia City, Minia Governorate, Egypt. Electronic address: nashwa.abdo@minia.edu.eg., Rifaai RA; Department of Histology and Cell Biology, Minia University, Faculty of Medicine, Minia City, Minia Governorate, Egypt., Saber EA; Department of Histology and Cell Biology, Minia University, Faculty of Medicine, Minia City, Minia Governorate, Egypt; Deraya University, New Minia City, Minia Governorate, Egypt., El-Aleem SAA; Department of Histology and Cell Biology, Minia University, Faculty of Medicine, Minia City, Minia Governorate, Egypt., Mohammed HH; Department of Histology and Cell Biology, Minia University, Faculty of Medicine, Minia City, Minia Governorate, Egypt.
Jazyk: angličtina
Zdroj: Journal of chemical neuroanatomy [J Chem Neuroanat] 2023 Oct; Vol. 132, pp. 102307. Date of Electronic Publication: 2023 Jul 04.
DOI: 10.1016/j.jchemneu.2023.102307
Abstrakt: Memory deficit, anxiety, coordination deficit and depression are common neurological disorders attributed to aluminum (Al) buildup in the nervous system. Quercetin nanoparticles (QNPs) are a newly developed effective neuroprotectant. We aimed to investigate the potential protective and therapeutic effects of QNPs in Al induced toxicity in rat cerebellum. A rat model of Al-induced cerebellar damage was created by AlCl 3 (100 mg/kg) administration orally for 42 days. QNPs (30 mg/kg) was administered for 42-days as a prophylactic (along with AlCl 3 administration) or therapeutic for 42-days (following AlCl 3 induced cerebellar damage). Cerebellar tissues were assessed for structural and molecular changes. The results showed that Al induced profound cerebellar structural and molecular changes, including neuronal damage, astrogliosis and tyrosine hydroxylase downregulation. Prophylactic QNPs significantly reduced Al induced cerebellar neuronal degeneration. QNPs is a promising neuroprotectant that can be used in elderly and vulnerable subjects to protect against neurological deterioration. It could be a promising new line for therapeutic intervention in neurodegenerative diseases.
Competing Interests: Competing interests The authors have no relevant financial or non-financial interests to disclose.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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