Ribosome subunits are upregulated in brain samples of a subgroup of individuals with schizophrenia: A systematic gene expression meta-analysis.

Autor: Mekiten O; Faculty of Medicine, Tel-Aviv University, Israel., Yitzhaky A; Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel., Gould N; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Rosenblum K; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel; Center for Gene Manipulation in the Brain, University of Haifa, Haifa, Israel., Hertzberg L; Faculty of Medicine, Tel-Aviv University, Israel; Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel; Shalvata Mental Health Center, Israel. Electronic address: libi.hertzberg@gmail.com.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2023 Aug; Vol. 164, pp. 372-381. Date of Electronic Publication: 2023 Jun 30.
DOI: 10.1016/j.jpsychires.2023.06.013
Abstrakt: One of the new theories accounting for the underlying pathophysiology of schizophrenia is excitation/inhibition imbalance. Interestingly, perturbation in protein synthesis machinery as well as oxidative stress can lead to excitation/inhibition imbalance. We thus performed a systematic meta-analysis of the expression of 79 ribosome subunit genes and two oxidative-stress related genes, HIF1A and NQO1, in brain samples of individuals with schizophrenia vs. healthy controls. We integrated 12 gene expression datasets, following the PRISMA guidelines (overall 511 samples, 253 schizophrenia and 258 controls). Five ribosome subunit genes were significantly upregulated in a subgroup of the patients with schizophrenia, while 24 (30%) showed a tendency for upregulation. HIF1A and NQO1 were also found to be significantly upregulated. Moreover, HIF1A and NQO1 showed positive correlation with the expression of the upregulated ribosome subunit genes. Our results, together with previous findings, suggest a possible role for altered mRNA translation in the pathogenesis of schizophrenia, in association with markers of increased oxidative stress in a subgroup of patients. Further studies should define whether the upregulation of ribosome subunits result in altered mRNA translation, which proteins are modulated and how it characterizes a subgroup of the patients with schizophrenia.
Competing Interests: Declaration of competing interest The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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