Prepectoral Two-Stage Implant-Based Breast Reconstruction with Poly-4-Hydroxybutyrate for Pocket Control without the Use of Acellular Dermal Matrix: A 4-Year Review.

Autor:	Movassaghi K; From Oregon Health Science University; Movassaghi Plastic Surgery and Ziba Medical Spa; AG Aesthetic Center; private practice; Illume Cosmetic Surgery and Medspa; and the University of California, Los Angeles., Gilson A; From Oregon Health Science University; Movassaghi Plastic Surgery and Ziba Medical Spa; AG Aesthetic Center; private practice; Illume Cosmetic Surgery and Medspa; and the University of California, Los Angeles., Stewart CN; From Oregon Health Science University; Movassaghi Plastic Surgery and Ziba Medical Spa; AG Aesthetic Center; private practice; Illume Cosmetic Surgery and Medspa; and the University of California, Los Angeles., Cusic J; From Oregon Health Science University; Movassaghi Plastic Surgery and Ziba Medical Spa; AG Aesthetic Center; private practice; Illume Cosmetic Surgery and Medspa; and the University of California, Los Angeles., Movassaghi A; From Oregon Health Science University; Movassaghi Plastic Surgery and Ziba Medical Spa; AG Aesthetic Center; private practice; Illume Cosmetic Surgery and Medspa; and the University of California, Los Angeles.
Jazyk:	angličtina
Zdroj:	Plastic and reconstructive surgery [Plast Reconstr Surg] 2024 Jul 01; Vol. 154 (1), pp. 15-24. Date of Electronic Publication: 2023 Jul 06.
DOI:	10.1097/PRS.0000000000010914
Abstrakt:	Background: Absorbable mesh has been used to mitigate the potential drawbacks of acellular dermal matrix (ADM)-based breast reconstruction. Poly-4-hydroxybutyrate (P4HB) has been demonstrated to be a lower-cost, safe, and effective alternative to ADM in subpectoral breast reconstruction. In this study, the authors used P4HB for pocket control and implant support in immediate two-stage prepectoral breast reconstruction, examining nonintegration, capsular contracture, implant malposition, patient comorbidities, and risk factors. Methods: A retrospective review of a single surgeon's (K.M.) experience was performed over a 4-year span for patients who had undergone immediate two-stage prepectoral implant-based breast reconstruction with P4HB mesh. Complications (implant loss, rippling, capsular contracture, and malposition) and patient satisfaction were examined. Results: From 2018 to 2022, 105 patients underwent breast reconstruction using P4HB mesh on a total of 194 breasts. P4HB mesh integration was 97%. Sixteen breasts (8.2%) experienced minor complications, and 10.3% of devices required explantation, which was significantly higher in the irradiated group at 28.6% ( P < 0.01). Patients who were older, had a higher body mass index, were active smokers, or had an increased mastectomy specimen size were more likely to undergo explantation. The capsular contracture rate and overall lateral malposition rate were 1.0%. Visible rippling was present in 15.6% of breasts. There was no significant difference between smile mastopexy and inferolateral incision with regard to capsular contracture, lateral malposition, and rippling. Overall, patients demonstrated a high level of satisfaction. There were no significant predictors of capsular contracture, lateral malposition, or visible rippling. Conclusions: The authors show the safety and efficacy of P4HB in two-stage prepectoral breast reconstruction. There appears to be equal, if not reduced, capsular contracture rates when compared with the published data on ADM. This represents a large cost reduction to both the patient and the health care system. Clinical Question/level of Evidence: Therapeutic, IV. (Copyright © 2023 by the American Society of Plastic Surgeons.)
Databáze:	MEDLINE
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