Four New Flavonoid C-Glycosides Isolated from Achyranthes aspera and Their Nitric Oxide Production Inhibitory Activities.

Autor: Tuyet Lan HT; Faculty of of Basic Sciences, University of Transport and Communications, Cau Giay, Lang Thuong, Dong Da, 10072, Hanoi, Vietnam., Mai NT; Faculty of of Basic Sciences, University of Transport and Communications, Cau Giay, Lang Thuong, Dong Da, 10072, Hanoi, Vietnam., Mai Anh BT; Faculty of of Basic Sciences, University of Transport and Communications, Cau Giay, Lang Thuong, Dong Da, 10072, Hanoi, Vietnam., Dung DT; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Van Kiem P; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam., Huu Tai B; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam.; Faculty of Chemistry, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, 10072, Hanoi, Vietnam.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2023 Aug; Vol. 20 (8), pp. e202300853. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1002/cbdv.202300853
Abstrakt: A chemical study of the methanol extract of the aerial parts of Achyranthes aspera led to the isolation of four new flavonoid C-glycosides (1-4) along with eight known analogs (5-12). Their structures were elucidated by a combination of spectroscopic data analysis, HR-ESI-MS, 1D and 2D NMR spectra. All the isolates were evaluated their NO production inhibitory activity in LPS-activated RAW264.7 cells. Compounds 2, 4, and 8-11 showed significant inhibition with IC 50 values ranging from 25.06 to 45.25 μM, compared to that of the positive control compound, L-NMMA, IC 50 value of 32.24 μM, whereas the remaining compounds were weak inhibitory activity with IC 50 values over 100 μM. This is the first report of 7 from Amaranthaceae family, and 11 from the genus Achyranthes.
(© 2023 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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