Aggregation-induced type I&II photosensitivity and photodegradability-based molecular backbones for synergistic antibacterial and cancer phototherapy via photodynamic and photothermal therapies.

Autor:	Liu J; School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan, China. ustbliujun@iccas.ac.cn., Chen H; School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan, China. ustbliujun@iccas.ac.cn., Yang Y; School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan, China. ustbliujun@iccas.ac.cn., Wang Q; College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu, 611130, China. guoweideng86@163.com., Zhang S; School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan, China. ustbliujun@iccas.ac.cn., Zhao B; School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan, China. ustbliujun@iccas.ac.cn., Li Z; School of Pharmacy and Institute of Pharmacy, North Sichuan Medical College, Sichuan, China. ustbliujun@iccas.ac.cn., Yang G; Institute of Chemistry & University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, China. gqyang@iccas.ac.cn., Deng G; College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu, 611130, China. guoweideng86@163.com.
Jazyk:	angličtina
Zdroj:	Materials horizons [Mater Horiz] 2023 Aug 29; Vol. 10 (9), pp. 3791-3796. Date of Electronic Publication: 2023 Aug 29.
DOI:	10.1039/d3mh00688c
Abstrakt:	The clinical applications of phototherapy nanomaterials are still limited due to concerns regarding their phototoxicity and efficacy. Herein, we report a novel type of D-π-A molecular backbone that induces type I/II photosensitivity and photodegradability by forming J-aggregates. The photodegradation rate can be regulated by changing the donor groups to regulate the photosensitivity of their aggregates because the photodegradability performance results from their oxidation by 1 O 2 generated by their type II photosensitivity. AID4 NPs possess faster photodegradation because of their better type I&II photosensitivity, which can also self-regulate by inhibiting type II and improving type I under hypoxic conditions. Moreover, they exhibited good photothermal and photoacoustic performance for improving their therapeutic effect by a synergistic effect and achieving photoacoustic imaging in vivo . The experimental result also showed that they can be effective for antibacterial and anti-tumor treatment and the photodegradation products of AID4 NPs possess low biological toxicity in the dark or under light. This study could provide a novel strategy for improving the safety and treatment effects of phototherapy.
Databáze:	MEDLINE
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