Elevated Serum Galectin-1 and Galectin-3 Levels in Children With Specific Learning Disorder: A Case Control Study.

Autor:	Tanır Y; Department of Child and Adolescent Psychiatry, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye., Gülle ZN; Department of Child and Adolescent Psychiatry, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye., Uncu GS; Department of Child and Adolescent Psychiatry, University of Health Science Van Training and Research Hospital, Van, Türkiye., Baki AM; Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye., Vural P; Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye., Soylu N; Department of Child and Adolescent Psychiatry, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye., Örengül AC; Department of Child and Adolescent Psychiatry, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye.
Jazyk:	angličtina
Zdroj:	Psychiatry investigation [Psychiatry Investig] 2023 Jul; Vol. 20 (7), pp. 609-615. Date of Electronic Publication: 2023 Jul 07.
DOI:	10.30773/pi.2023.0048
Abstrakt:	Objective: Specific learning disorder (SLD) is a neurodevelopmental disorder in which underlying pathogenesis and etiological factors are not fully understood. Neuroinflammatory response (measured with serum levels of galectin-1 and galectin-3), which is associated with learning and memory, may play an important role in the etiopathogenesis of SLD. Aim of the present study is to examine whether serum galectin-1 and galectin-3 levels are related to SLD. Methods: The current study consisted of 42 treatment-naive children with SLD and 42 control subjects. All of the subjects were assessed using semi-structured psychiatric examination to diagnose SLD and exclude attention-deficit hyperactivity disorder. Serum galectin-1 and galectin-3 levels were measured via venous blood samples. Results: The SLD and control group did not differ significantly in terms of age, sex, and body mass index (BMI). The SLD group had significantly higher serum levels of galectin-1 (8.78±2.97 vs. 7.40±2.03, p=0.019) and galectin-3 (1.86±0.93 vs. 1.32±0.69, p=0.003) than the control group when controlled for age, sex, and BMI. Conclusion: Higher serum levels of galectin-1 and galectin-3 in children with SLD may indicate the role of neuroinflammatory response in the pathogenesis of SLD. Other mechanisms involving galectin-1 and galectin-3 related to learning may play a part in the etiology of SLD.
Databáze:	MEDLINE
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