Intrinsically disordered proteins and conformational noise: The hypothesis a decade later.
| Autor: | Kulkarni P; Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.; Department of Systems Biology, City of Hope National Medical Center, Duarte, CA, USA., Salgia R; Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA., Rangarajan G; Department of Mathematics, Indian Institute of Science, Bangalore 560012, India.; Center for Neuroscience, Indian Institute of Science, Bangalore 560012, India. |
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| Jazyk: | angličtina |
| Zdroj: | IScience [iScience] 2023 Jun 15; Vol. 26 (7), pp. 107109. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023). |
| DOI: | 10.1016/j.isci.2023.107109 |
| Abstrakt: | Phenotypic plasticity is the ability of individual genotypes to produce different phenotypes in response to environmental perturbations. We previously postulated how conformational noise emanating from conformational dynamics of intrinsically disordered proteins (IDPs) which is distinct from transcriptional noise, can contribute to phenotypic switching by rewiring the cellular protein interaction network. Since most transcription factors are IDPs, we posited that conformational noise is an integral component of transcriptional noise implying that IDPs may amplify total noise in the system either stochastically or in response to environmental changes. Here, we review progress in elucidating the details of the hypothesis. We highlight empirical evidence supporting the hypothesis, discuss conceptual advances that underscore its fundamental importance and implications, and identify areas for future investigations. Competing Interests: The authors declare no competing interests. (© 2023 The Author(s).) |
| Databáze: | MEDLINE |
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