| Autor: |
Nielsen SY; Department of Clinical Microbiology, Vejle Hospital, University hospital of Southern Denmark, Vejle, Denmark.; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.; Department Biomedicine, Aarhus University, Aarhus, Denmark., Murra M; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark., Pedersen LH; Department Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.; Clinical Medicine, Aarhus University, Aarhus, Denmark., Khalil MR; Department of Obstetrics and Gynecology, Kolding Hospital, University hospital of Southern Denmark, Kolding, Denmark., Hvidman L; Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark., Helmig RB; Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark., Møller JK; Department of Clinical Microbiology, Vejle Hospital, University hospital of Southern Denmark, Vejle, Denmark., Kirkeby M; Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark., Rosbjerg AM; Department of Obstetrics and Gynecology, Kolding Hospital, University hospital of Southern Denmark, Kolding, Denmark., Henriksen TB; Clinical Medicine, Aarhus University, Aarhus, Denmark.; Child and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark. |
| Abstrakt: |
Background: In a country with a high-test frequency, societal lockdown, and pregnancy leave granted from 28 gestational weeks, we investigated SARS-CoV-2 infection in women admitted in labor and their newborn in the pre-vaccine period. Material and methods: A total of 1042 women admitted for delivery in two Danish hospitals agreed to a plasma sample and nasopharyngeal, vaginal, and rectal swabs and to sampling of umbilical cord blood and a nasopharyngeal swab from their newborn at delivery. Plasma samples from women were examined for SARS-CoV-2 antibodies. If antibodies were detected, or the woman had a positive nasopharyngeal swab upon admission or had a household contact with symptoms consistent with COVID-19, SARS-CoV-2 PCR was performed on plasma and swab samples from mother and child. Results: Seventeen women (1.6%) were seropositive. Half the newborn ( n = 9 (53%)) of seropositive mothers were also seropositive. None of the seropositive women or newborns had clinical signs of COVID-19 and all had SARS-CoV-2 PCR negative plasma and swab samples. Conclusion: Adherence to specific national guidelines pertaining to testing, self-imposed isolation, and cautious behaviors among pregnant women likely contributed to the exceptionally low prevalence of both prior and current COVID-19 infections detected at the time of childbirth preceding the routine vaccination of pregnant women in Denmark. |
