The European Society for Blood and Marrow Transplantation (EBMT) roadmap and perspectives to improve nutritional care in patients undergoing hematopoietic stem cell transplantation on behalf of the Cellular Therapy and Immunobiology Working Party (CTIWP) and the Nurses Group (NG) of the EBMT.

Autor: Casirati A; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Salcedo I; Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Madrid, Spain., Cereda E; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Chabannon C; Centre de Thérapie Cellulaire & Centre d'Investigations Cliniques en Biothérapies Inserm CBT-1409, Institut Paoli-Calmettes, Marseille, France., Ruggeri A; Hematology and BMT Unit, San Raffaele Scientific Institute, Milan, Italy., Kuball J; Department of Hematology and Center for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands., Clout R; Department of Haematology and Transplant Unit, The Christie Hospital, Manchester, United Kingdom., Mooyaart JE; EBMT Statistical Unit, Leiden, The Netherlands., Kenyon M; Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom., Caccialanza R; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Pedrazzoli P; Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy. p.pedrazzoli@smatteo.pv.it.; Department of Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. p.pedrazzoli@smatteo.pv.it., Kisch AM; Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden and Institute of Health Sciences, Lund University, Lund, Sweden.
Jazyk: angličtina
Zdroj: Bone marrow transplantation [Bone Marrow Transplant] 2023 Sep; Vol. 58 (9), pp. 965-972. Date of Electronic Publication: 2023 Jul 05.
DOI: 10.1038/s41409-023-02018-z
Abstrakt: Malnutrition is the most common comorbidity during the continuum of hematopoietic stem cell transplant (HSCT) and negatively impacts clinical outcomes, response to therapy, quality of life, and costs. The intensive conditioning regimen administered before transplant causes inflammatory damages to the gastrointestinal system, which themselves contribute to trigger graft versus host disease (GvHD) in the allogeneic setting. GvHD and other post-transplant complications such as infections adversely affect food intake and gut absorption of nutrients. Consequently, patients exhibit signs of malnutrition such as weight loss and muscle wasting, thus triggering a "vicious circle" that favours additional complications. Among HSCT centres, there is marked variability in nutritional care, from screening for malnutrition to nutritional intervention. The present paper, elaborated by the Cellular Therapy and Immunobiology Working Party and the Nurses Group of the European Society for Blood and Marrow Transplantation, aims at defining a roadmap that identifies the main nutritional critical issues in the field of HSCT. This document will be propaedeutic to the development of clinical algorithms to counteract risk factors of malnutrition, based on scientific evidence and shared among HSCT centres, and thus maximize transplant outcomes.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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