Rutin ameliorates nitrergic and endothelial dysfunction on vessels and corpora cavernosa of diabetic animals.

Autor: de Morais Campos R; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., Lima LMALL; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., da Silva AG; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., Santiago RO; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., Paz IA; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., Cabral PHB; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., Santos CF; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., Fonteles MC; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil., do Nascimento NRF; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil.. Electronic address: nilberto.nascimento@uece.br.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2023 Aug; Vol. 161, pp. 163-172. Date of Electronic Publication: 2023 Jun 28.
DOI: 10.1016/j.rvsc.2023.06.020
Abstrakt: Endothelial dysfunction is an early complication of diabetes and it is related to both micro- and macroangiopathies. In addition, >70% of diabetic patients develop autonomic neuropathies. Increased oxidative stress has a major role in the development of both nitrergic and endothelial dysfunction. The aim of this work is to evaluate whether rutin, a potent antioxidant, could ameliorate nitrergic and/or endothelial dysfunction in diabetic animals. Primary and secondary treatment protocols with rutin were investigated on rat aortic rings and the mesenteric arteriolar bed, and on rabbit aortic rings and corpora cavernosa (RbCC) from both euglycemic and alloxan-diabetic animals. Acetylcholine endothelium-dependent and sodium nitroprusside endothelium-independent relaxations were compared in tissues from euglycemic or diabetic animals. Electrical field stimulation (EFS)-induced relaxation was performed only in the RbCC. Endothelial-dependent relaxations were blunted by 40% in vessels and neuronal relaxation was blunted by 50% in RbCC taken from diabetic animals when compared to euglycemic animals. Pre-treatment with rutin restored both neuronal and endothelial dependent relaxations in diabetic animals towards the values achieved in control euglycemic tissues. Rutin was able to ameliorate both endothelial dysfunction and nitrergic neuropathy in animal experimental models. Rutin could be a lead compound in the primary or secondary preventive ancillary treatment of endothelial and nitrergic dysfunction in the course of diabetes.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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