The expression of CD86 in CD3 + CD56 + NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study.

Autor: Chen SL; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China.; Medical College, Shantou University, Shantou, 515041, Guangdong, China.; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China.; The Second School of Clinical Medicine, Southern Medical University, 1063 Shatai Nan Road, Guangzhou, 510515, China., Liu XY; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China., Huang JH; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China.; School of Medicine, South China University of Technology, Guangzhou, 510006, China., Xian LH; Laboratory Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China., Li XS; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China., Wang KR; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Li J; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China.; The Second School of Clinical Medicine, Southern Medical University, 1063 Shatai Nan Road, Guangzhou, 510515, China., Zhang TC; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China.; Medical College, Shantou University, Shantou, 515041, Guangdong, China., Huang GG; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China.; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China., Liu XQ; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China., Zeng HK; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China., Zhou MH; Laboratory Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China. zhoumaohua@gdph.org.cn., Jiang WQ; Department of Emergency&Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China. jiangwenqiang@gdph.org.cn.; Medical College, Shantou University, Shantou, 515041, Guangdong, China. jiangwenqiang@gdph.org.cn.; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, Guangdong, China. jiangwenqiang@gdph.org.cn.; The Second School of Clinical Medicine, Southern Medical University, 1063 Shatai Nan Road, Guangzhou, 510515, China. jiangwenqiang@gdph.org.cn.; School of Medicine, South China University of Technology, Guangzhou, 510006, China. jiangwenqiang@gdph.org.cn.
Jazyk: angličtina
Zdroj: Immunologic research [Immunol Res] 2023 Dec; Vol. 71 (6), pp. 929-940. Date of Electronic Publication: 2023 Jul 05.
DOI: 10.1007/s12026-023-09405-0
Abstrakt: The role of CD3 + CD56 + natural killer T (NKT) cells and its co-signaling molecules in patients with sepsis-associated encephalopathy (SAE) is unknown. In this prospective observational cohort study, we initially recruited 260 septic patients and eventually analyzed 90 patients, of whom 57 were in the SAE group and 37 were in the non-SAE group. Compared to the non-SAE group, 28-day mortality was significantly increased in the SAE group (33.3% vs. 12.1%, p = 0.026), while the mean fluorescence intensity (MFI) of CD86 in CD3 + CD56 + NKT cells was significantly lower (2065.8 (1625.5 ~ 3198.8) vs. 3117.8 (2278.1 ~ 5349), p = 0.007). Multivariate analysis showed that MFI of CD86 in NKT cells, APACHE II score, and serum albumin were independent risk factors for SAE. Furthermore, the Kaplan-Meier survival analysis indicated that the mortality rate was significantly higher in the high-risk group than in the low-risk group (χ 2  = 14.779, p < 0.001). This study showed that the decreased expression of CD86 in CD3 + CD56 + NKT cells is an independent risk factor of SAE; thus, a prediction model including MFI of CD86 in NKT cells, APACHE II score, and serum albumin can be constructed for diagnosing SAE and predicting prognosis.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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