Targeting autophagy with tamoxifen in breast cancer: From molecular mechanisms to targeted therapy.

Autor: Zamanian MY; Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran., Golmohammadi M; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Nili-Ahmadabadi A; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran., Alameri AA; Department of Chemistry, College of Science, University of Babylon, Babylon, Iraq., Al-Hassan M; Department of Nursing, University of Calgary in Qatar, Doha, Qatar., Alshahrani SH; Medical Surgical Nursing Department, King Khalid University, Khamis Mushait, Saudi Arabia., Hasan MS; Department of Anesthesia Techniques, Al-Mustaqbal University College, Babylon, Iraq., Ramírez-Coronel AA; Azogues Campus Nursing Career, Health and Behavior Research group (HBR), Psychometry and Ethology Laboratory, Catholic University of Cuenca, Cuenca, Ecuador.; University of Palermo, Buenos Aires, Argentina.; Research Group in Educational Statistics, National University of Education, Azogues, Ecuador.; Epidemiology and Biostatistics Research Group, CES University, Medellín, Colombia., Qasim QA; College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq., Heidari M; Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran., Verma A; Bioorganic and Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagari, India.
Jazyk: angličtina
Zdroj: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Dec; Vol. 37 (6), pp. 1092-1108. Date of Electronic Publication: 2023 Jul 04.
DOI: 10.1111/fcp.12936
Abstrakt: Background: Tamoxifen (TAM) is often recommended as a first-line treatment for estrogen receptor-positive breast cancer (BC). However, TAM resistance continues to be a medical challenge for BC with hormone receptor positivity. The function of macro-autophagy and autophagy has recently been identified to be altered in BC, which suggests a potential mechanism for TAM resistance. Autophagy is a cellular stress-induced response to preserve cellular homeostasis. Also, therapy-induced autophagy, which is typically cytoprotective and activated in tumor cells, could sometimes be non-protective, cytostatic, or cytotoxic depending on how it is regulated.
Objective: This review explored the literature on the connections between hormonal therapies and autophagy. We investigated how autophagy could develop drug resistance in BC cells.
Methods: Scopus, Science Direct, PubMed, and Google Scholar were used to search articles for this study.
Results: The results demonstrated that protein kinases such as pAMPK, BAX, and p-p70S6K could be a sign of autophagy in developing TAM resistance. According to the study's findings, autophagy plays an important role in BC patients' TAM resistance.
Conclusion: Therefore, by overcoming endocrine resistance in estrogen receptor-positive breast tumors, autophagy inhibition may improve the therapeutic efficacy of TAM.
(© 2023 Société Française de Pharmacologie et de Thérapeutique.)
Databáze: MEDLINE
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